Cargando…

Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease

Background and aims: Our goals in the study were to (1) quantify the discordance in LDL-C levels between equations (the Friedewald, Sampson, and Martin/Hopkins equations) and compare them with direct LDL-C (dLDL-C); and (2) explore the proportion of misclassified patients by calculated LDL-C using t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Boqun, Wang, Hao-Yu, Yin, Dong, Zhu, Chenggang, Feng, Lei, Wang, Hongjian, Jia, Lei, Fu, Rui, Song, Chenxi, Zhou, Zhou, Lin, Yahui, Song, Weihua, Dou, Ke-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604394/
https://www.ncbi.nlm.nih.gov/pubmed/36286294
http://dx.doi.org/10.3390/jcdd9100342
_version_ 1784817803070537728
author Shi, Boqun
Wang, Hao-Yu
Yin, Dong
Zhu, Chenggang
Feng, Lei
Wang, Hongjian
Jia, Lei
Fu, Rui
Song, Chenxi
Zhou, Zhou
Lin, Yahui
Song, Weihua
Dou, Ke-Fei
author_facet Shi, Boqun
Wang, Hao-Yu
Yin, Dong
Zhu, Chenggang
Feng, Lei
Wang, Hongjian
Jia, Lei
Fu, Rui
Song, Chenxi
Zhou, Zhou
Lin, Yahui
Song, Weihua
Dou, Ke-Fei
author_sort Shi, Boqun
collection PubMed
description Background and aims: Our goals in the study were to (1) quantify the discordance in LDL-C levels between equations (the Friedewald, Sampson, and Martin/Hopkins equations) and compare them with direct LDL-C (dLDL-C); and (2) explore the proportion of misclassified patients by calculated LDL-C using these three different equations. Methods: A total of 30,349 consecutive patients with angiographically confirmed coronary artery disease (CAD) were prospectively enrolled. Concordance was defined as if the LDL-C was <1.8 mmol/L with each pairwise comparison of LDL-C equations. Estimated LDL-C that fell into the same category as dLDL-C at the following levels: <1.4, 1.4 to 1.7, 1.8 to 2.5, 2.6 to 2.9, and ≥3.0 mmol/L was considered to have been correctly categorized. Results: The concordance was 96.3% (Sampson vs. Martin/Hopkins), 95.0% (Friedewald vs. Sampson), and 91.4% (Friedewald vs. Martin/Hopkins), respectively. This proportion fell to 82.4% in those with hypertriglyceridemia (TG ≥ 1.7 mmol/L). With an accurate classification rate of 73.6%, the Martin/Hopkins equation outperformed the Sampson equation (69.5%) and the Friedewald equation (59.3%) by a wide margin. Conclusions: Comparing it to the validated Martin/Hopkins equation, the Friedewald equation produced the lowest levels of LDL-C, followed by the Sampson equation. In the classification of LDL-C, the Martin/Hopkins equation has also been shown to be more accurate. There is a significant difference between the equations and the direct measurement method, which may lead to overtreatment or undertreatment.
format Online
Article
Text
id pubmed-9604394
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96043942022-10-27 Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease Shi, Boqun Wang, Hao-Yu Yin, Dong Zhu, Chenggang Feng, Lei Wang, Hongjian Jia, Lei Fu, Rui Song, Chenxi Zhou, Zhou Lin, Yahui Song, Weihua Dou, Ke-Fei J Cardiovasc Dev Dis Article Background and aims: Our goals in the study were to (1) quantify the discordance in LDL-C levels between equations (the Friedewald, Sampson, and Martin/Hopkins equations) and compare them with direct LDL-C (dLDL-C); and (2) explore the proportion of misclassified patients by calculated LDL-C using these three different equations. Methods: A total of 30,349 consecutive patients with angiographically confirmed coronary artery disease (CAD) were prospectively enrolled. Concordance was defined as if the LDL-C was <1.8 mmol/L with each pairwise comparison of LDL-C equations. Estimated LDL-C that fell into the same category as dLDL-C at the following levels: <1.4, 1.4 to 1.7, 1.8 to 2.5, 2.6 to 2.9, and ≥3.0 mmol/L was considered to have been correctly categorized. Results: The concordance was 96.3% (Sampson vs. Martin/Hopkins), 95.0% (Friedewald vs. Sampson), and 91.4% (Friedewald vs. Martin/Hopkins), respectively. This proportion fell to 82.4% in those with hypertriglyceridemia (TG ≥ 1.7 mmol/L). With an accurate classification rate of 73.6%, the Martin/Hopkins equation outperformed the Sampson equation (69.5%) and the Friedewald equation (59.3%) by a wide margin. Conclusions: Comparing it to the validated Martin/Hopkins equation, the Friedewald equation produced the lowest levels of LDL-C, followed by the Sampson equation. In the classification of LDL-C, the Martin/Hopkins equation has also been shown to be more accurate. There is a significant difference between the equations and the direct measurement method, which may lead to overtreatment or undertreatment. MDPI 2022-10-07 /pmc/articles/PMC9604394/ /pubmed/36286294 http://dx.doi.org/10.3390/jcdd9100342 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Boqun
Wang, Hao-Yu
Yin, Dong
Zhu, Chenggang
Feng, Lei
Wang, Hongjian
Jia, Lei
Fu, Rui
Song, Chenxi
Zhou, Zhou
Lin, Yahui
Song, Weihua
Dou, Ke-Fei
Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title_full Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title_fullStr Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title_full_unstemmed Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title_short Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease
title_sort comparison of estimated ldl cholesterol equations with direct measurement in patients with angiographically confirmed coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604394/
https://www.ncbi.nlm.nih.gov/pubmed/36286294
http://dx.doi.org/10.3390/jcdd9100342
work_keys_str_mv AT shiboqun comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT wanghaoyu comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT yindong comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT zhuchenggang comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT fenglei comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT wanghongjian comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT jialei comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT furui comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT songchenxi comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT zhouzhou comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT linyahui comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT songweihua comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease
AT doukefei comparisonofestimatedldlcholesterolequationswithdirectmeasurementinpatientswithangiographicallyconfirmedcoronaryarterydisease