Rational Mutagenesis in the Lid Domain of Ribokinase from E. coli Results in an Order of Magnitude Increase in Activity towards D-arabinose

Development of efficient approaches for the production of medically important nucleosides is a highly relevant challenge for biotechnology. In particular, cascade synthesis of arabinosides would allow relatively easy production of various cytostatic and antiviral drugs. However, the biocatalyst nece...

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Detalles Bibliográficos
Autores principales: Zayats, Evgeniy A., Fateev, Ilya V., Kostromina, Maria A., Abramchik, Yulia A., Lykoshin, Dmitry D., Yurovskaya, Daria O., Timofeev, Vladimir I., Berzina, Maria Ya., Eletskaya, Barbara Z., Konstantinova, Irina D., Esipov, Roman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604405/
https://www.ncbi.nlm.nih.gov/pubmed/36293391
http://dx.doi.org/10.3390/ijms232012540

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