Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death

Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress and inflammation, limiting its clinical use. Herein, we looked into the effect of punicalagin (PU), a polyphenolic...

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Detalles Bibliográficos
Autores principales: Al-khawalde, Alayn’ Al-marddyah A., Abukhalil, Mohammad H., Jghef, Muthana M., Alfwuaires, Manal A., Alaryani, Fatima S., Aladaileh, Saleem H., Algefare, Abdulmohsen I., Karimulla, Shaik, Alasmari, Fawaz, Aldal’in, Hammad Khalifeh, Alanezi, Abdulkareem A., Althunibat, Osama Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604463/
https://www.ncbi.nlm.nih.gov/pubmed/36293191
http://dx.doi.org/10.3390/ijms232012334

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