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Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604473/ https://www.ncbi.nlm.nih.gov/pubmed/36293263 http://dx.doi.org/10.3390/ijms232012409 |
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author | Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Gładki, Marcin Michalak, Michał Sochacki, Mateusz Weclewska, Anita Zalas, Dominika Bobkowski, Waldemar Jemielity, Marek |
author_facet | Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Gładki, Marcin Michalak, Michał Sochacki, Mateusz Weclewska, Anita Zalas, Dominika Bobkowski, Waldemar Jemielity, Marek |
author_sort | Urbanowicz, Tomasz |
collection | PubMed |
description | Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’ risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3–30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery. |
format | Online Article Text |
id | pubmed-9604473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96044732022-10-27 Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Gładki, Marcin Michalak, Michał Sochacki, Mateusz Weclewska, Anita Zalas, Dominika Bobkowski, Waldemar Jemielity, Marek Int J Mol Sci Communication Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’ risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3–30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery. MDPI 2022-10-17 /pmc/articles/PMC9604473/ /pubmed/36293263 http://dx.doi.org/10.3390/ijms232012409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Gładki, Marcin Michalak, Michał Sochacki, Mateusz Weclewska, Anita Zalas, Dominika Bobkowski, Waldemar Jemielity, Marek Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title | Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title_full | Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title_fullStr | Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title_full_unstemmed | Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title_short | Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery |
title_sort | neutrophil count as atrioventricular block (avb) predictor following pediatric heart surgery |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604473/ https://www.ncbi.nlm.nih.gov/pubmed/36293263 http://dx.doi.org/10.3390/ijms232012409 |
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