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Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery

Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’...

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Autores principales: Urbanowicz, Tomasz, Olasińska-Wiśniewska, Anna, Gładki, Marcin, Michalak, Michał, Sochacki, Mateusz, Weclewska, Anita, Zalas, Dominika, Bobkowski, Waldemar, Jemielity, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604473/
https://www.ncbi.nlm.nih.gov/pubmed/36293263
http://dx.doi.org/10.3390/ijms232012409
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author Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Gładki, Marcin
Michalak, Michał
Sochacki, Mateusz
Weclewska, Anita
Zalas, Dominika
Bobkowski, Waldemar
Jemielity, Marek
author_facet Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Gładki, Marcin
Michalak, Michał
Sochacki, Mateusz
Weclewska, Anita
Zalas, Dominika
Bobkowski, Waldemar
Jemielity, Marek
author_sort Urbanowicz, Tomasz
collection PubMed
description Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’ risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3–30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery.
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spelling pubmed-96044732022-10-27 Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Gładki, Marcin Michalak, Michał Sochacki, Mateusz Weclewska, Anita Zalas, Dominika Bobkowski, Waldemar Jemielity, Marek Int J Mol Sci Communication Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’ risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3–30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery. MDPI 2022-10-17 /pmc/articles/PMC9604473/ /pubmed/36293263 http://dx.doi.org/10.3390/ijms232012409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Gładki, Marcin
Michalak, Michał
Sochacki, Mateusz
Weclewska, Anita
Zalas, Dominika
Bobkowski, Waldemar
Jemielity, Marek
Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title_full Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title_fullStr Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title_full_unstemmed Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title_short Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery
title_sort neutrophil count as atrioventricular block (avb) predictor following pediatric heart surgery
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604473/
https://www.ncbi.nlm.nih.gov/pubmed/36293263
http://dx.doi.org/10.3390/ijms232012409
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