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Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficul...

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Autores principales: Ausra, Jokubas, Madrid, Micah, Yin, Rose T., Hanna, Jessica, Arnott, Suzanne, Brennan, Jaclyn A., Peralta, Roberto, Clausen, David, Bakall, Jakob A., Efimov, Igor R., Gutruf, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604544/
https://www.ncbi.nlm.nih.gov/pubmed/36288311
http://dx.doi.org/10.1126/sciadv.abq7469
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author Ausra, Jokubas
Madrid, Micah
Yin, Rose T.
Hanna, Jessica
Arnott, Suzanne
Brennan, Jaclyn A.
Peralta, Roberto
Clausen, David
Bakall, Jakob A.
Efimov, Igor R.
Gutruf, Philipp
author_facet Ausra, Jokubas
Madrid, Micah
Yin, Rose T.
Hanna, Jessica
Arnott, Suzanne
Brennan, Jaclyn A.
Peralta, Roberto
Clausen, David
Bakall, Jakob A.
Efimov, Igor R.
Gutruf, Philipp
author_sort Ausra, Jokubas
collection PubMed
description Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.
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spelling pubmed-96045442022-11-04 Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation Ausra, Jokubas Madrid, Micah Yin, Rose T. Hanna, Jessica Arnott, Suzanne Brennan, Jaclyn A. Peralta, Roberto Clausen, David Bakall, Jakob A. Efimov, Igor R. Gutruf, Philipp Sci Adv Physical and Materials Sciences Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject. American Association for the Advancement of Science 2022-10-26 /pmc/articles/PMC9604544/ /pubmed/36288311 http://dx.doi.org/10.1126/sciadv.abq7469 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Ausra, Jokubas
Madrid, Micah
Yin, Rose T.
Hanna, Jessica
Arnott, Suzanne
Brennan, Jaclyn A.
Peralta, Roberto
Clausen, David
Bakall, Jakob A.
Efimov, Igor R.
Gutruf, Philipp
Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title_full Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title_fullStr Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title_full_unstemmed Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title_short Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
title_sort wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604544/
https://www.ncbi.nlm.nih.gov/pubmed/36288311
http://dx.doi.org/10.1126/sciadv.abq7469
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