Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation

Legumain is a lysosomal cysteine protease with strict specificity for cleaving after asparagine residues. By sequence comparison, legumain belongs to MEROPS clan CD of the cysteine proteases, which indicates its structural and mechanistic relation to caspases. Contrasting caspases, legumain harbors...

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Detalles Bibliográficos
Autores principales: Elamin, Tasneem, Brandstetter, Hans, Dall, Elfriede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604545/
https://www.ncbi.nlm.nih.gov/pubmed/36293424
http://dx.doi.org/10.3390/ijms232012548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604545/
https://www.ncbi.nlm.nih.gov/pubmed/36293424
http://dx.doi.org/10.3390/ijms232012548

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