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Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation
Legumain is a lysosomal cysteine protease with strict specificity for cleaving after asparagine residues. By sequence comparison, legumain belongs to MEROPS clan CD of the cysteine proteases, which indicates its structural and mechanistic relation to caspases. Contrasting caspases, legumain harbors...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604545/ https://www.ncbi.nlm.nih.gov/pubmed/36293424 http://dx.doi.org/10.3390/ijms232012548 |