Cargando…

Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to red...

Descripción completa

Detalles Bibliográficos
Autores principales: Dragasevic, Sanja, Stankovic, Biljana, Kotur, Nikola, Milutinovic, Aleksandra Sokic, Milovanovic, Tamara, Stojkovic Lalosevic, Milica, Stojanovic, Maja, Pavlovic, Sonja, Popovic, Dragan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604584/
https://www.ncbi.nlm.nih.gov/pubmed/36295058
http://dx.doi.org/10.3390/life12101623
_version_ 1784817850810105856
author Dragasevic, Sanja
Stankovic, Biljana
Kotur, Nikola
Milutinovic, Aleksandra Sokic
Milovanovic, Tamara
Stojkovic Lalosevic, Milica
Stojanovic, Maja
Pavlovic, Sonja
Popovic, Dragan
author_facet Dragasevic, Sanja
Stankovic, Biljana
Kotur, Nikola
Milutinovic, Aleksandra Sokic
Milovanovic, Tamara
Stojkovic Lalosevic, Milica
Stojanovic, Maja
Pavlovic, Sonja
Popovic, Dragan
author_sort Dragasevic, Sanja
collection PubMed
description Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment.
format Online
Article
Text
id pubmed-9604584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96045842022-10-27 Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease Dragasevic, Sanja Stankovic, Biljana Kotur, Nikola Milutinovic, Aleksandra Sokic Milovanovic, Tamara Stojkovic Lalosevic, Milica Stojanovic, Maja Pavlovic, Sonja Popovic, Dragan Life (Basel) Review Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment. MDPI 2022-10-18 /pmc/articles/PMC9604584/ /pubmed/36295058 http://dx.doi.org/10.3390/life12101623 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dragasevic, Sanja
Stankovic, Biljana
Kotur, Nikola
Milutinovic, Aleksandra Sokic
Milovanovic, Tamara
Stojkovic Lalosevic, Milica
Stojanovic, Maja
Pavlovic, Sonja
Popovic, Dragan
Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title_full Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title_fullStr Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title_full_unstemmed Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title_short Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
title_sort genetic aspects of micronutrients important for inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604584/
https://www.ncbi.nlm.nih.gov/pubmed/36295058
http://dx.doi.org/10.3390/life12101623
work_keys_str_mv AT dragasevicsanja geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT stankovicbiljana geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT koturnikola geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT milutinovicaleksandrasokic geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT milovanovictamara geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT stojkoviclalosevicmilica geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT stojanovicmaja geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT pavlovicsonja geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease
AT popovicdragan geneticaspectsofmicronutrientsimportantforinflammatoryboweldisease