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Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604751/ https://www.ncbi.nlm.nih.gov/pubmed/36286298 http://dx.doi.org/10.3390/jcdd9100346 |
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author | He, Yang Chen, Du Xu, Jing-Ping Jin, Jun Wang, Jun Geng, Cong He, Yong-Ming |
author_facet | He, Yang Chen, Du Xu, Jing-Ping Jin, Jun Wang, Jun Geng, Cong He, Yong-Ming |
author_sort | He, Yang |
collection | PubMed |
description | Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension. |
format | Online Article Text |
id | pubmed-9604751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96047512022-10-27 Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population He, Yang Chen, Du Xu, Jing-Ping Jin, Jun Wang, Jun Geng, Cong He, Yong-Ming J Cardiovasc Dev Dis Article Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension. MDPI 2022-10-10 /pmc/articles/PMC9604751/ /pubmed/36286298 http://dx.doi.org/10.3390/jcdd9100346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article He, Yang Chen, Du Xu, Jing-Ping Jin, Jun Wang, Jun Geng, Cong He, Yong-Ming Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title | Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title_full | Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title_fullStr | Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title_full_unstemmed | Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title_short | Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population |
title_sort | association between serum uric acid and hypertension in a large cross-section study in a chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604751/ https://www.ncbi.nlm.nih.gov/pubmed/36286298 http://dx.doi.org/10.3390/jcdd9100346 |
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