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Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population

Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted f...

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Autores principales: He, Yang, Chen, Du, Xu, Jing-Ping, Jin, Jun, Wang, Jun, Geng, Cong, He, Yong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604751/
https://www.ncbi.nlm.nih.gov/pubmed/36286298
http://dx.doi.org/10.3390/jcdd9100346
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author He, Yang
Chen, Du
Xu, Jing-Ping
Jin, Jun
Wang, Jun
Geng, Cong
He, Yong-Ming
author_facet He, Yang
Chen, Du
Xu, Jing-Ping
Jin, Jun
Wang, Jun
Geng, Cong
He, Yong-Ming
author_sort He, Yang
collection PubMed
description Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension.
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spelling pubmed-96047512022-10-27 Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population He, Yang Chen, Du Xu, Jing-Ping Jin, Jun Wang, Jun Geng, Cong He, Yong-Ming J Cardiovasc Dev Dis Article Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension. MDPI 2022-10-10 /pmc/articles/PMC9604751/ /pubmed/36286298 http://dx.doi.org/10.3390/jcdd9100346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Yang
Chen, Du
Xu, Jing-Ping
Jin, Jun
Wang, Jun
Geng, Cong
He, Yong-Ming
Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title_full Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title_fullStr Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title_full_unstemmed Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title_short Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population
title_sort association between serum uric acid and hypertension in a large cross-section study in a chinese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604751/
https://www.ncbi.nlm.nih.gov/pubmed/36286298
http://dx.doi.org/10.3390/jcdd9100346
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