A Review of the Abscopal Effect in the Era of Immunotherapy

The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The...

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Detalles Bibliográficos
Autores principales: Nabrinsky, Edward, Macklis, Jason, Bitran, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Radiation Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604762/
https://www.ncbi.nlm.nih.gov/pubmed/36321062
http://dx.doi.org/10.7759/cureus.29620
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author Nabrinsky, Edward
Macklis, Jason
Bitran, Jacob
author_facet Nabrinsky, Edward
Macklis, Jason
Bitran, Jacob
author_sort Nabrinsky, Edward
collection PubMed
description The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The combination of radiation therapy and immune checkpoint inhibition (ICI) acts at several stages of the antitumor response, suggesting a mechanism of synergy between the two modalities. This review focuses on recent advances in the understanding of the effect of radiation and immunotherapy in the context of the abscopal effect.
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spelling pubmed-96047622022-10-31 A Review of the Abscopal Effect in the Era of Immunotherapy Nabrinsky, Edward Macklis, Jason Bitran, Jacob Cureus Radiation Oncology The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The combination of radiation therapy and immune checkpoint inhibition (ICI) acts at several stages of the antitumor response, suggesting a mechanism of synergy between the two modalities. This review focuses on recent advances in the understanding of the effect of radiation and immunotherapy in the context of the abscopal effect. Cureus 2022-09-26 /pmc/articles/PMC9604762/ /pubmed/36321062 http://dx.doi.org/10.7759/cureus.29620 Text en Copyright © 2022, Nabrinsky et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiation Oncology
Nabrinsky, Edward
Macklis, Jason
Bitran, Jacob
A Review of the Abscopal Effect in the Era of Immunotherapy
title A Review of the Abscopal Effect in the Era of Immunotherapy
title_full A Review of the Abscopal Effect in the Era of Immunotherapy
title_fullStr A Review of the Abscopal Effect in the Era of Immunotherapy
title_full_unstemmed A Review of the Abscopal Effect in the Era of Immunotherapy
title_short A Review of the Abscopal Effect in the Era of Immunotherapy
title_sort review of the abscopal effect in the era of immunotherapy
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604762/
https://www.ncbi.nlm.nih.gov/pubmed/36321062
http://dx.doi.org/10.7759/cureus.29620
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