A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition characterized by café-au-lait spots, cutaneous neurofibromas, axillary and inguinal freckling, and iris Lisch nodules; however, the presentations vary greatly, even within families. NF1 is also a recognized risk factor for the develop...

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Autores principales: Baddi, Fatima Zahra, Ahsayen, Fatima Zohra, Ramdani, Hiba, Rhazari, Meriem, Skiker, Imane, Thouil, Afaf, Kouismi, Hatim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604765/
https://www.ncbi.nlm.nih.gov/pubmed/36321000
http://dx.doi.org/10.7759/cureus.29621
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author Baddi, Fatima Zahra
Ahsayen, Fatima Zohra
Ramdani, Hiba
Rhazari, Meriem
Skiker, Imane
Thouil, Afaf
Kouismi, Hatim
author_facet Baddi, Fatima Zahra
Ahsayen, Fatima Zohra
Ramdani, Hiba
Rhazari, Meriem
Skiker, Imane
Thouil, Afaf
Kouismi, Hatim
author_sort Baddi, Fatima Zahra
collection PubMed
description Neurofibromatosis type 1 (NF1) is an autosomal dominant condition characterized by café-au-lait spots, cutaneous neurofibromas, axillary and inguinal freckling, and iris Lisch nodules; however, the presentations vary greatly, even within families. NF1 is also a recognized risk factor for the development of malignancy particularly malignant peripheral nerve sheath tumors (MPNST), optic gliomas, other gliomas, and leukemia. Nevertheless, the occurrence of lung cancer in a patient with neurofibromatosis type 1 is a rare phenomenon. Here we present a case of neuroendocrine tumor in a patient with neurofibromatosis type 1, highlighting the association between the two diseases. This case report also aimed to raise awareness of possible malignancies in patients with neurofibromatosis type 1.
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spelling pubmed-96047652022-10-31 A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association? Baddi, Fatima Zahra Ahsayen, Fatima Zohra Ramdani, Hiba Rhazari, Meriem Skiker, Imane Thouil, Afaf Kouismi, Hatim Cureus Pathology Neurofibromatosis type 1 (NF1) is an autosomal dominant condition characterized by café-au-lait spots, cutaneous neurofibromas, axillary and inguinal freckling, and iris Lisch nodules; however, the presentations vary greatly, even within families. NF1 is also a recognized risk factor for the development of malignancy particularly malignant peripheral nerve sheath tumors (MPNST), optic gliomas, other gliomas, and leukemia. Nevertheless, the occurrence of lung cancer in a patient with neurofibromatosis type 1 is a rare phenomenon. Here we present a case of neuroendocrine tumor in a patient with neurofibromatosis type 1, highlighting the association between the two diseases. This case report also aimed to raise awareness of possible malignancies in patients with neurofibromatosis type 1. Cureus 2022-09-26 /pmc/articles/PMC9604765/ /pubmed/36321000 http://dx.doi.org/10.7759/cureus.29621 Text en Copyright © 2022, Baddi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Baddi, Fatima Zahra
Ahsayen, Fatima Zohra
Ramdani, Hiba
Rhazari, Meriem
Skiker, Imane
Thouil, Afaf
Kouismi, Hatim
A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title_full A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title_fullStr A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title_full_unstemmed A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title_short A Rare Case of Neuroendocrine Tumor in a Patient With Neurofibromatosis Type 1: Is There Any Association?
title_sort rare case of neuroendocrine tumor in a patient with neurofibromatosis type 1: is there any association?
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604765/
https://www.ncbi.nlm.nih.gov/pubmed/36321000
http://dx.doi.org/10.7759/cureus.29621
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