Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial

Background: a specific subset of metastatic triple-negative breast cancers (mTNBC) is characterized by homologous recombination deficiency (HRD), leading to enhanced sensitivity to platinum-based chemotherapy. Apart from mutations in BRCA1/2 genes, the evaluation of other HRD-related alterations has...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonnet, Elise, Haddad, Véronique, Quesada, Stanislas, Baffert, Kim-Arthur, Lardy-Cléaud, Audrey, Treilleux, Isabelle, Pissaloux, Daniel, Attignon, Valéry, Wang, Qing, Buisson, Adrien, Heudel, Pierre-Etienne, Bachelot, Thomas, Dufresne, Armelle, Eberst, Lauriane, Toussaint, Philippe, Bonadona, Valérie, Lasset, Christine, Viari, Alain, Sohier, Emilie, Paindavoine, Sandrine, Combaret, Valérie, Pérol, David, Ray-Coquard, Isabelle, Blay, Jean-Yves, Trédan, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604780/
https://www.ncbi.nlm.nih.gov/pubmed/36294734
http://dx.doi.org/10.3390/jpm12101595

Ejemplares similares

Ejemplares similares