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Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes

Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional R...

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Autores principales: Zhou, Saijun, Dong, Rongna, Wang, Junmei, Zhang, Li, Yu, Bai, Shao, Xian, Bai, Pufei, Zhang, Rui, Ma, Yongjian, Yu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604792/
https://www.ncbi.nlm.nih.gov/pubmed/36294877
http://dx.doi.org/10.3390/jpm12101738
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author Zhou, Saijun
Dong, Rongna
Wang, Junmei
Zhang, Li
Yu, Bai
Shao, Xian
Bai, Pufei
Zhang, Rui
Ma, Yongjian
Yu, Pei
author_facet Zhou, Saijun
Dong, Rongna
Wang, Junmei
Zhang, Li
Yu, Bai
Shao, Xian
Bai, Pufei
Zhang, Rui
Ma, Yongjian
Yu, Pei
author_sort Zhou, Saijun
collection PubMed
description Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional RBC lifespan detection means. In this study, we monitored 464 T2DM patients and 231 healthy control finger blood glucose levels at seven time points for three consecutive months. The HbA1c levels were assessed at the end of the third month as well as the RBC lifespan was measured through the CO breath test. T2DM patients were stratified into four quartile groups according to their RBC lifespans. There was no statistical significance in HbA1c among these four groups. However, the average blood glucose in the Q1 group was significantly higher than those in the other groups. Additionally, the contribution of RBC lifespan to HbA1c test value in the Q1 group was 14.07%, which was significantly higher than those in the other groups. Finally, we used multiple linear regression models to construct a mathematical formula to correct the HbA1c test value in the Q1 group, which would benefit the management of T2DM.
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spelling pubmed-96047922022-10-27 Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes Zhou, Saijun Dong, Rongna Wang, Junmei Zhang, Li Yu, Bai Shao, Xian Bai, Pufei Zhang, Rui Ma, Yongjian Yu, Pei J Pers Med Article Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional RBC lifespan detection means. In this study, we monitored 464 T2DM patients and 231 healthy control finger blood glucose levels at seven time points for three consecutive months. The HbA1c levels were assessed at the end of the third month as well as the RBC lifespan was measured through the CO breath test. T2DM patients were stratified into four quartile groups according to their RBC lifespans. There was no statistical significance in HbA1c among these four groups. However, the average blood glucose in the Q1 group was significantly higher than those in the other groups. Additionally, the contribution of RBC lifespan to HbA1c test value in the Q1 group was 14.07%, which was significantly higher than those in the other groups. Finally, we used multiple linear regression models to construct a mathematical formula to correct the HbA1c test value in the Q1 group, which would benefit the management of T2DM. MDPI 2022-10-19 /pmc/articles/PMC9604792/ /pubmed/36294877 http://dx.doi.org/10.3390/jpm12101738 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Saijun
Dong, Rongna
Wang, Junmei
Zhang, Li
Yu, Bai
Shao, Xian
Bai, Pufei
Zhang, Rui
Ma, Yongjian
Yu, Pei
Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title_full Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title_fullStr Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title_full_unstemmed Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title_short Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
title_sort red blood cell lifespan < 74 days can clinically reduce hb1ac levels in type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604792/
https://www.ncbi.nlm.nih.gov/pubmed/36294877
http://dx.doi.org/10.3390/jpm12101738
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