Cargando…

Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet

Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet facto...

Descripción completa

Detalles Bibliográficos
Autores principales: Seidita, Aurelio, Mansueto, Pasquale, Compagnoni, Stella, Castellucci, Daniele, Soresi, Maurizio, Chiarello, Giorgio, Cavallo, Giorgia, De Carlo, Gabriele, Nigro, Alessia, Chiavetta, Marta, Mandreucci, Francesca, Giuliano, Alessandra, Disclafani, Rosaria, Carroccio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604793/
https://www.ncbi.nlm.nih.gov/pubmed/36294721
http://dx.doi.org/10.3390/jpm12101582
_version_ 1784817904067280896
author Seidita, Aurelio
Mansueto, Pasquale
Compagnoni, Stella
Castellucci, Daniele
Soresi, Maurizio
Chiarello, Giorgio
Cavallo, Giorgia
De Carlo, Gabriele
Nigro, Alessia
Chiavetta, Marta
Mandreucci, Francesca
Giuliano, Alessandra
Disclafani, Rosaria
Carroccio, Antonio
author_facet Seidita, Aurelio
Mansueto, Pasquale
Compagnoni, Stella
Castellucci, Daniele
Soresi, Maurizio
Chiarello, Giorgio
Cavallo, Giorgia
De Carlo, Gabriele
Nigro, Alessia
Chiavetta, Marta
Mandreucci, Francesca
Giuliano, Alessandra
Disclafani, Rosaria
Carroccio, Antonio
author_sort Seidita, Aurelio
collection PubMed
description Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet factors influencing anemia persistence. We retrospectively analyzed CD patients admitted to three centers between 2016–2020. 159 patients entered the study (129 females). More than half (54.7%) had mild-moderate, hypochromic and microcytic anemia, associated with below normal total serum iron and ferritin, indicative of iron deficiency anemia (IDA). One year after diagnosis, 134 patients were following ‘strict’ GFD. Hypochromic and microcytic anemia persisted in 46% of subjects who were anemic at diagnosis. Patients with persistent anemia had at diagnosis a higher prevalence of female gender (p = 0.02), lower body mass index (BMI, p = 0.01), higher prevalence of poly/hypermenorrhea (p = 0.02) and atopy (p = 0.04), and lower ferritin levels (p = 0.05) than the whole group of non-anemic ones. IDA is found in more than 50% of CD patients at diagnosis; nevertheless, in a lot of women IDA is not corrected by ‘strict’ GFD. Low BMI and poly/hypermenorrhea at diagnosis characterize this subgroup, suggesting that IDA might be due to iron loss rather than malabsorption, or to their coexistence/overlap.
format Online
Article
Text
id pubmed-9604793
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96047932022-10-27 Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet Seidita, Aurelio Mansueto, Pasquale Compagnoni, Stella Castellucci, Daniele Soresi, Maurizio Chiarello, Giorgio Cavallo, Giorgia De Carlo, Gabriele Nigro, Alessia Chiavetta, Marta Mandreucci, Francesca Giuliano, Alessandra Disclafani, Rosaria Carroccio, Antonio J Pers Med Article Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet factors influencing anemia persistence. We retrospectively analyzed CD patients admitted to three centers between 2016–2020. 159 patients entered the study (129 females). More than half (54.7%) had mild-moderate, hypochromic and microcytic anemia, associated with below normal total serum iron and ferritin, indicative of iron deficiency anemia (IDA). One year after diagnosis, 134 patients were following ‘strict’ GFD. Hypochromic and microcytic anemia persisted in 46% of subjects who were anemic at diagnosis. Patients with persistent anemia had at diagnosis a higher prevalence of female gender (p = 0.02), lower body mass index (BMI, p = 0.01), higher prevalence of poly/hypermenorrhea (p = 0.02) and atopy (p = 0.04), and lower ferritin levels (p = 0.05) than the whole group of non-anemic ones. IDA is found in more than 50% of CD patients at diagnosis; nevertheless, in a lot of women IDA is not corrected by ‘strict’ GFD. Low BMI and poly/hypermenorrhea at diagnosis characterize this subgroup, suggesting that IDA might be due to iron loss rather than malabsorption, or to their coexistence/overlap. MDPI 2022-09-26 /pmc/articles/PMC9604793/ /pubmed/36294721 http://dx.doi.org/10.3390/jpm12101582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seidita, Aurelio
Mansueto, Pasquale
Compagnoni, Stella
Castellucci, Daniele
Soresi, Maurizio
Chiarello, Giorgio
Cavallo, Giorgia
De Carlo, Gabriele
Nigro, Alessia
Chiavetta, Marta
Mandreucci, Francesca
Giuliano, Alessandra
Disclafani, Rosaria
Carroccio, Antonio
Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title_full Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title_fullStr Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title_full_unstemmed Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title_short Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
title_sort anemia in celiac disease: prevalence, associated clinical and laboratory features, and persistence after gluten-free diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604793/
https://www.ncbi.nlm.nih.gov/pubmed/36294721
http://dx.doi.org/10.3390/jpm12101582
work_keys_str_mv AT seiditaaurelio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT mansuetopasquale anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT compagnonistella anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT castelluccidaniele anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT soresimaurizio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT chiarellogiorgio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT cavallogiorgia anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT decarlogabriele anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT nigroalessia anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT chiavettamarta anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT mandreuccifrancesca anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT giulianoalessandra anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT disclafanirosaria anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet
AT carroccioantonio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet