Cargando…
Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet
Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet facto...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604793/ https://www.ncbi.nlm.nih.gov/pubmed/36294721 http://dx.doi.org/10.3390/jpm12101582 |
_version_ | 1784817904067280896 |
---|---|
author | Seidita, Aurelio Mansueto, Pasquale Compagnoni, Stella Castellucci, Daniele Soresi, Maurizio Chiarello, Giorgio Cavallo, Giorgia De Carlo, Gabriele Nigro, Alessia Chiavetta, Marta Mandreucci, Francesca Giuliano, Alessandra Disclafani, Rosaria Carroccio, Antonio |
author_facet | Seidita, Aurelio Mansueto, Pasquale Compagnoni, Stella Castellucci, Daniele Soresi, Maurizio Chiarello, Giorgio Cavallo, Giorgia De Carlo, Gabriele Nigro, Alessia Chiavetta, Marta Mandreucci, Francesca Giuliano, Alessandra Disclafani, Rosaria Carroccio, Antonio |
author_sort | Seidita, Aurelio |
collection | PubMed |
description | Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet factors influencing anemia persistence. We retrospectively analyzed CD patients admitted to three centers between 2016–2020. 159 patients entered the study (129 females). More than half (54.7%) had mild-moderate, hypochromic and microcytic anemia, associated with below normal total serum iron and ferritin, indicative of iron deficiency anemia (IDA). One year after diagnosis, 134 patients were following ‘strict’ GFD. Hypochromic and microcytic anemia persisted in 46% of subjects who were anemic at diagnosis. Patients with persistent anemia had at diagnosis a higher prevalence of female gender (p = 0.02), lower body mass index (BMI, p = 0.01), higher prevalence of poly/hypermenorrhea (p = 0.02) and atopy (p = 0.04), and lower ferritin levels (p = 0.05) than the whole group of non-anemic ones. IDA is found in more than 50% of CD patients at diagnosis; nevertheless, in a lot of women IDA is not corrected by ‘strict’ GFD. Low BMI and poly/hypermenorrhea at diagnosis characterize this subgroup, suggesting that IDA might be due to iron loss rather than malabsorption, or to their coexistence/overlap. |
format | Online Article Text |
id | pubmed-9604793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96047932022-10-27 Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet Seidita, Aurelio Mansueto, Pasquale Compagnoni, Stella Castellucci, Daniele Soresi, Maurizio Chiarello, Giorgio Cavallo, Giorgia De Carlo, Gabriele Nigro, Alessia Chiavetta, Marta Mandreucci, Francesca Giuliano, Alessandra Disclafani, Rosaria Carroccio, Antonio J Pers Med Article Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet factors influencing anemia persistence. We retrospectively analyzed CD patients admitted to three centers between 2016–2020. 159 patients entered the study (129 females). More than half (54.7%) had mild-moderate, hypochromic and microcytic anemia, associated with below normal total serum iron and ferritin, indicative of iron deficiency anemia (IDA). One year after diagnosis, 134 patients were following ‘strict’ GFD. Hypochromic and microcytic anemia persisted in 46% of subjects who were anemic at diagnosis. Patients with persistent anemia had at diagnosis a higher prevalence of female gender (p = 0.02), lower body mass index (BMI, p = 0.01), higher prevalence of poly/hypermenorrhea (p = 0.02) and atopy (p = 0.04), and lower ferritin levels (p = 0.05) than the whole group of non-anemic ones. IDA is found in more than 50% of CD patients at diagnosis; nevertheless, in a lot of women IDA is not corrected by ‘strict’ GFD. Low BMI and poly/hypermenorrhea at diagnosis characterize this subgroup, suggesting that IDA might be due to iron loss rather than malabsorption, or to their coexistence/overlap. MDPI 2022-09-26 /pmc/articles/PMC9604793/ /pubmed/36294721 http://dx.doi.org/10.3390/jpm12101582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Seidita, Aurelio Mansueto, Pasquale Compagnoni, Stella Castellucci, Daniele Soresi, Maurizio Chiarello, Giorgio Cavallo, Giorgia De Carlo, Gabriele Nigro, Alessia Chiavetta, Marta Mandreucci, Francesca Giuliano, Alessandra Disclafani, Rosaria Carroccio, Antonio Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title | Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title_full | Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title_fullStr | Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title_full_unstemmed | Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title_short | Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet |
title_sort | anemia in celiac disease: prevalence, associated clinical and laboratory features, and persistence after gluten-free diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604793/ https://www.ncbi.nlm.nih.gov/pubmed/36294721 http://dx.doi.org/10.3390/jpm12101582 |
work_keys_str_mv | AT seiditaaurelio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT mansuetopasquale anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT compagnonistella anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT castelluccidaniele anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT soresimaurizio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT chiarellogiorgio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT cavallogiorgia anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT decarlogabriele anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT nigroalessia anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT chiavettamarta anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT mandreuccifrancesca anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT giulianoalessandra anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT disclafanirosaria anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet AT carroccioantonio anemiainceliacdiseaseprevalenceassociatedclinicalandlaboratoryfeaturesandpersistenceafterglutenfreediet |