Cargando…

Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Periodontitis is characterized by low-grade inflammation of the periodontal tissues, the structures that support and connect the teeth to the maxilla and mandible. This inflammation is caused by the accumulation of subgingival bacterial biofilm and gradually leads to the extensive damage of these ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Gheorghe, Dorin Nicolae, Bennardo, Francesco, Popescu, Dora Maria, Nicolae, Flavia Mirela, Ionele, Claudiu Marinel, Boldeanu, Mihail Virgil, Camen, Adrian, Rogoveanu, Ion, Surlin, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604856/
https://www.ncbi.nlm.nih.gov/pubmed/36294719
http://dx.doi.org/10.3390/jpm12101580
_version_ 1784817919768657920
author Gheorghe, Dorin Nicolae
Bennardo, Francesco
Popescu, Dora Maria
Nicolae, Flavia Mirela
Ionele, Claudiu Marinel
Boldeanu, Mihail Virgil
Camen, Adrian
Rogoveanu, Ion
Surlin, Petra
author_facet Gheorghe, Dorin Nicolae
Bennardo, Francesco
Popescu, Dora Maria
Nicolae, Flavia Mirela
Ionele, Claudiu Marinel
Boldeanu, Mihail Virgil
Camen, Adrian
Rogoveanu, Ion
Surlin, Petra
author_sort Gheorghe, Dorin Nicolae
collection PubMed
description Periodontitis is characterized by low-grade inflammation of the periodontal tissues, the structures that support and connect the teeth to the maxilla and mandible. This inflammation is caused by the accumulation of subgingival bacterial biofilm and gradually leads to the extensive damage of these tissues and the consequent loss of teeth. Hepatitis B is a major global health concern; infection with the hepatitis B virus causes significant inflammation of the liver and the possibility of its gradual evolution to cirrhosis. Hepatitis D, caused by infection with the delta hepatitis virus, is manifest only in patients already infected with the type B virus in a simultaneous (co-infected) or superimposed (superinfected) manner. The dental and periodontal status of patients with hepatitis B/D could exhibit significant changes, increasing the risk of periodontitis onset. Moreover, the progression of liver changes in these patients could be linked to periodontitis; therefore, motivating good oral and periodontal health could result in the prevention and limitation of pathological effects. Given that both types of diseases have a significant inflammatory component, common pro-inflammatory mediators could drive and augment the local inflammation at both a periodontal and hepatic level. This suggests that integrated management of these patients should be proposed, as therapeutical means could deliver an improvement to both periodontal and hepatic statuses. The aim of this review is to gather existing information on the proposed subject and to organize significant data in order to improve scientific accuracy and comprehension on this topic while generating future perspectives for research.
format Online
Article
Text
id pubmed-9604856
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96048562022-10-27 Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives Gheorghe, Dorin Nicolae Bennardo, Francesco Popescu, Dora Maria Nicolae, Flavia Mirela Ionele, Claudiu Marinel Boldeanu, Mihail Virgil Camen, Adrian Rogoveanu, Ion Surlin, Petra J Pers Med Review Periodontitis is characterized by low-grade inflammation of the periodontal tissues, the structures that support and connect the teeth to the maxilla and mandible. This inflammation is caused by the accumulation of subgingival bacterial biofilm and gradually leads to the extensive damage of these tissues and the consequent loss of teeth. Hepatitis B is a major global health concern; infection with the hepatitis B virus causes significant inflammation of the liver and the possibility of its gradual evolution to cirrhosis. Hepatitis D, caused by infection with the delta hepatitis virus, is manifest only in patients already infected with the type B virus in a simultaneous (co-infected) or superimposed (superinfected) manner. The dental and periodontal status of patients with hepatitis B/D could exhibit significant changes, increasing the risk of periodontitis onset. Moreover, the progression of liver changes in these patients could be linked to periodontitis; therefore, motivating good oral and periodontal health could result in the prevention and limitation of pathological effects. Given that both types of diseases have a significant inflammatory component, common pro-inflammatory mediators could drive and augment the local inflammation at both a periodontal and hepatic level. This suggests that integrated management of these patients should be proposed, as therapeutical means could deliver an improvement to both periodontal and hepatic statuses. The aim of this review is to gather existing information on the proposed subject and to organize significant data in order to improve scientific accuracy and comprehension on this topic while generating future perspectives for research. MDPI 2022-09-26 /pmc/articles/PMC9604856/ /pubmed/36294719 http://dx.doi.org/10.3390/jpm12101580 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gheorghe, Dorin Nicolae
Bennardo, Francesco
Popescu, Dora Maria
Nicolae, Flavia Mirela
Ionele, Claudiu Marinel
Boldeanu, Mihail Virgil
Camen, Adrian
Rogoveanu, Ion
Surlin, Petra
Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title_full Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title_fullStr Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title_full_unstemmed Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title_short Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives
title_sort oral and periodontal implications of hepatitis type b and d. current state of knowledge and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604856/
https://www.ncbi.nlm.nih.gov/pubmed/36294719
http://dx.doi.org/10.3390/jpm12101580
work_keys_str_mv AT gheorghedorinnicolae oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT bennardofrancesco oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT popescudoramaria oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT nicolaeflaviamirela oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT ioneleclaudiumarinel oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT boldeanumihailvirgil oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT camenadrian oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT rogoveanuion oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives
AT surlinpetra oralandperiodontalimplicationsofhepatitistypebanddcurrentstateofknowledgeandfutureperspectives