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Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019

Background: Historically, acute kidney injury (AKI) has been a common severe complication of acute myocardial infarction (MI). As percutaneous coronary interventions have become more widely used, AMI outcomes have significantly improved. However, post-AMI AKI epidemiology and its associated factors...

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Autores principales: Wang, Wen-Hwa, Hong, Yu-Cyuan, Chen, Hsiu-Min, Chen, David, Wei, Kai-Che, Lai, Ping-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604918/
https://www.ncbi.nlm.nih.gov/pubmed/36294404
http://dx.doi.org/10.3390/jcm11206083
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author Wang, Wen-Hwa
Hong, Yu-Cyuan
Chen, Hsiu-Min
Chen, David
Wei, Kai-Che
Lai, Ping-Chin
author_facet Wang, Wen-Hwa
Hong, Yu-Cyuan
Chen, Hsiu-Min
Chen, David
Wei, Kai-Che
Lai, Ping-Chin
author_sort Wang, Wen-Hwa
collection PubMed
description Background: Historically, acute kidney injury (AKI) has been a common severe complication of acute myocardial infarction (MI). As percutaneous coronary interventions have become more widely used, AMI outcomes have significantly improved. However, post-AMI AKI epidemiology and its associated factors are not well-understood in the age of interventional cardiology. Materials and methods: This is a retrospective study examining changes in creatinine levels in all patients admitted for AMI in a single medical center between August 2009 and February 2019. KDIGO criteria were used to define the different stages of post-AMI AKI. Results: The study included 1299 eligible cases, among which 213 (16.4%) developed AKI during AMI index admission; and 128 (60.1%), 46 (21.6%), and 39 (18.3%) were classified as KDIGO stages 1, 2, and 3, respectively. Compared with non-AKI subjects, the AKI group had a higher prevalence of non-STEMI (48.4% vs. 29.1%, p < 0.001), higher Killip class (3 or 4), and higher in-hospital mortality (15% vs. 2.5%, p < 0.001). During the index MI hospitalization, 13.6% (29/213) of the post-MI AKI patients received hemodialysis. Baseline abnormal creatinine (≥1.5 mg/dL), dyslipidemia, and more advanced KDIGO stages (2 or 3) were associated with an increased risk of requiring in-hospital hemodialysis. Moreover, a more advanced KDIGO stage (≥2) was correlated with higher all-cause in-hospital mortality. Conclusion: AMI patients remain at risk of AKI, which negatively affects their survival in the modern age.
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spelling pubmed-96049182022-10-27 Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019 Wang, Wen-Hwa Hong, Yu-Cyuan Chen, Hsiu-Min Chen, David Wei, Kai-Che Lai, Ping-Chin J Clin Med Article Background: Historically, acute kidney injury (AKI) has been a common severe complication of acute myocardial infarction (MI). As percutaneous coronary interventions have become more widely used, AMI outcomes have significantly improved. However, post-AMI AKI epidemiology and its associated factors are not well-understood in the age of interventional cardiology. Materials and methods: This is a retrospective study examining changes in creatinine levels in all patients admitted for AMI in a single medical center between August 2009 and February 2019. KDIGO criteria were used to define the different stages of post-AMI AKI. Results: The study included 1299 eligible cases, among which 213 (16.4%) developed AKI during AMI index admission; and 128 (60.1%), 46 (21.6%), and 39 (18.3%) were classified as KDIGO stages 1, 2, and 3, respectively. Compared with non-AKI subjects, the AKI group had a higher prevalence of non-STEMI (48.4% vs. 29.1%, p < 0.001), higher Killip class (3 or 4), and higher in-hospital mortality (15% vs. 2.5%, p < 0.001). During the index MI hospitalization, 13.6% (29/213) of the post-MI AKI patients received hemodialysis. Baseline abnormal creatinine (≥1.5 mg/dL), dyslipidemia, and more advanced KDIGO stages (2 or 3) were associated with an increased risk of requiring in-hospital hemodialysis. Moreover, a more advanced KDIGO stage (≥2) was correlated with higher all-cause in-hospital mortality. Conclusion: AMI patients remain at risk of AKI, which negatively affects their survival in the modern age. MDPI 2022-10-15 /pmc/articles/PMC9604918/ /pubmed/36294404 http://dx.doi.org/10.3390/jcm11206083 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Wen-Hwa
Hong, Yu-Cyuan
Chen, Hsiu-Min
Chen, David
Wei, Kai-Che
Lai, Ping-Chin
Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title_full Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title_fullStr Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title_full_unstemmed Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title_short Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction—A Case Series Study from 2009 to 2019
title_sort risk factors and outcome of acute kidney injury following acute myocardial infarction—a case series study from 2009 to 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604918/
https://www.ncbi.nlm.nih.gov/pubmed/36294404
http://dx.doi.org/10.3390/jcm11206083
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