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Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic

The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds of thousands of human cases and severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although ZIKV was first isolated in Uganda, Africa has so...

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Autores principales: Rose, Noah H., Dabo, Stéphanie, da Veiga Leal, Silvânia, Sylla, Massamba, Diagne, Cheikh T., Faye, Oumar, Faye, Ousmane, Sall, Amadou A., McBride, Carolyn S., Lambrechts, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604947/
https://www.ncbi.nlm.nih.gov/pubmed/36288328
http://dx.doi.org/10.1371/journal.pbio.3001864
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author Rose, Noah H.
Dabo, Stéphanie
da Veiga Leal, Silvânia
Sylla, Massamba
Diagne, Cheikh T.
Faye, Oumar
Faye, Ousmane
Sall, Amadou A.
McBride, Carolyn S.
Lambrechts, Louis
author_facet Rose, Noah H.
Dabo, Stéphanie
da Veiga Leal, Silvânia
Sylla, Massamba
Diagne, Cheikh T.
Faye, Oumar
Faye, Ousmane
Sall, Amadou A.
McBride, Carolyn S.
Lambrechts, Louis
author_sort Rose, Noah H.
collection PubMed
description The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds of thousands of human cases and severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although ZIKV was first isolated in Uganda, Africa has so far been exempt from large-scale ZIKV epidemics, despite widespread susceptibility among African human populations. A possible explanation for this pattern is natural variation among populations of the primary vector of ZIKV, the mosquito Aedes aegypti. Globally invasive populations of Ae. aegypti outside of Africa are considered effective ZIKV vectors because they are human specialists with high intrinsic ZIKV susceptibility, whereas African populations of Ae. aegypti across the species’ native range are predominantly generalists with low intrinsic ZIKV susceptibility, making them less likely to spread viruses in the human population. We test this idea by studying a notable exception to the patterns observed across most of Africa: Cape Verde experienced a large ZIKV outbreak in 2015 to 2016. We find that local Ae. aegypti in Cape Verde have substantial human-specialist ancestry, show a robust behavioral preference for human hosts, and exhibit increased susceptibility to ZIKV infection, consistent with a key role for variation among mosquito populations in ZIKV epidemiology. These findings suggest that similar human-specialist populations of Ae. aegypti in the nearby Sahel region of West Africa, which may be expanding in response to rapid urbanization, could serve as effective vectors for ZIKV in the future.
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spelling pubmed-96049472022-10-27 Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic Rose, Noah H. Dabo, Stéphanie da Veiga Leal, Silvânia Sylla, Massamba Diagne, Cheikh T. Faye, Oumar Faye, Ousmane Sall, Amadou A. McBride, Carolyn S. Lambrechts, Louis PLoS Biol Short Reports The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds of thousands of human cases and severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although ZIKV was first isolated in Uganda, Africa has so far been exempt from large-scale ZIKV epidemics, despite widespread susceptibility among African human populations. A possible explanation for this pattern is natural variation among populations of the primary vector of ZIKV, the mosquito Aedes aegypti. Globally invasive populations of Ae. aegypti outside of Africa are considered effective ZIKV vectors because they are human specialists with high intrinsic ZIKV susceptibility, whereas African populations of Ae. aegypti across the species’ native range are predominantly generalists with low intrinsic ZIKV susceptibility, making them less likely to spread viruses in the human population. We test this idea by studying a notable exception to the patterns observed across most of Africa: Cape Verde experienced a large ZIKV outbreak in 2015 to 2016. We find that local Ae. aegypti in Cape Verde have substantial human-specialist ancestry, show a robust behavioral preference for human hosts, and exhibit increased susceptibility to ZIKV infection, consistent with a key role for variation among mosquito populations in ZIKV epidemiology. These findings suggest that similar human-specialist populations of Ae. aegypti in the nearby Sahel region of West Africa, which may be expanding in response to rapid urbanization, could serve as effective vectors for ZIKV in the future. Public Library of Science 2022-10-26 /pmc/articles/PMC9604947/ /pubmed/36288328 http://dx.doi.org/10.1371/journal.pbio.3001864 Text en © 2022 Rose et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Short Reports
Rose, Noah H.
Dabo, Stéphanie
da Veiga Leal, Silvânia
Sylla, Massamba
Diagne, Cheikh T.
Faye, Oumar
Faye, Ousmane
Sall, Amadou A.
McBride, Carolyn S.
Lambrechts, Louis
Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title_full Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title_fullStr Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title_full_unstemmed Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title_short Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic
title_sort enhanced mosquito vectorial capacity underlies the cape verde zika epidemic
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604947/
https://www.ncbi.nlm.nih.gov/pubmed/36288328
http://dx.doi.org/10.1371/journal.pbio.3001864
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