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Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary

Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from...

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Autores principales: Huin, Marine, Lorenzini, Jerome, Arbion, Flavie, Carcopino, Xavier, Touboul, Cyril, Dabi, Yohann, Kerbage, Yohan, Costaz, Hélène, Lecointre, Lise, Lavoué, Vincent, Bolze, Pierre-Adrien, Huchon, Cyrille, Bricou, Alexandre, Canlorbe, Geoffroy, Mimoun, Camille, Bendifallah, Sofiane, Gauthier, Tristan, Body, Gilles, Ouldamer, Lobna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605042/
https://www.ncbi.nlm.nih.gov/pubmed/36294441
http://dx.doi.org/10.3390/jcm11206120
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author Huin, Marine
Lorenzini, Jerome
Arbion, Flavie
Carcopino, Xavier
Touboul, Cyril
Dabi, Yohann
Kerbage, Yohan
Costaz, Hélène
Lecointre, Lise
Lavoué, Vincent
Bolze, Pierre-Adrien
Huchon, Cyrille
Bricou, Alexandre
Canlorbe, Geoffroy
Mimoun, Camille
Bendifallah, Sofiane
Gauthier, Tristan
Body, Gilles
Ouldamer, Lobna
author_facet Huin, Marine
Lorenzini, Jerome
Arbion, Flavie
Carcopino, Xavier
Touboul, Cyril
Dabi, Yohann
Kerbage, Yohan
Costaz, Hélène
Lecointre, Lise
Lavoué, Vincent
Bolze, Pierre-Adrien
Huchon, Cyrille
Bricou, Alexandre
Canlorbe, Geoffroy
Mimoun, Camille
Bendifallah, Sofiane
Gauthier, Tristan
Body, Gilles
Ouldamer, Lobna
author_sort Huin, Marine
collection PubMed
description Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. Results: A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic/para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Conclusions: Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course.
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spelling pubmed-96050422022-10-27 Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary Huin, Marine Lorenzini, Jerome Arbion, Flavie Carcopino, Xavier Touboul, Cyril Dabi, Yohann Kerbage, Yohan Costaz, Hélène Lecointre, Lise Lavoué, Vincent Bolze, Pierre-Adrien Huchon, Cyrille Bricou, Alexandre Canlorbe, Geoffroy Mimoun, Camille Bendifallah, Sofiane Gauthier, Tristan Body, Gilles Ouldamer, Lobna J Clin Med Article Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. Results: A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic/para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Conclusions: Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course. MDPI 2022-10-17 /pmc/articles/PMC9605042/ /pubmed/36294441 http://dx.doi.org/10.3390/jcm11206120 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huin, Marine
Lorenzini, Jerome
Arbion, Flavie
Carcopino, Xavier
Touboul, Cyril
Dabi, Yohann
Kerbage, Yohan
Costaz, Hélène
Lecointre, Lise
Lavoué, Vincent
Bolze, Pierre-Adrien
Huchon, Cyrille
Bricou, Alexandre
Canlorbe, Geoffroy
Mimoun, Camille
Bendifallah, Sofiane
Gauthier, Tristan
Body, Gilles
Ouldamer, Lobna
Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title_full Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title_fullStr Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title_full_unstemmed Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title_short Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary
title_sort presentation and prognosis of primary expansile and infiltrative mucinous carcinomas of the ovary
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605042/
https://www.ncbi.nlm.nih.gov/pubmed/36294441
http://dx.doi.org/10.3390/jcm11206120
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