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The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray...

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Autores principales: Koimtzis, Georgios, Stefanopoulos, Leandros, Brooker, Verity, Geropoulos, Georgios, Chalklin, Christopher G., Gupta, Sapna, Carrington-Windo, Eliot, Papaioannou, Maria, Papavramidis, Theodosios S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605053/
https://www.ncbi.nlm.nih.gov/pubmed/36295099
http://dx.doi.org/10.3390/life12101664
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author Koimtzis, Georgios
Stefanopoulos, Leandros
Brooker, Verity
Geropoulos, Georgios
Chalklin, Christopher G.
Gupta, Sapna
Carrington-Windo, Eliot
Papaioannou, Maria
Papavramidis, Theodosios S.
author_facet Koimtzis, Georgios
Stefanopoulos, Leandros
Brooker, Verity
Geropoulos, Georgios
Chalklin, Christopher G.
Gupta, Sapna
Carrington-Windo, Eliot
Papaioannou, Maria
Papavramidis, Theodosios S.
author_sort Koimtzis, Georgios
collection PubMed
description The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Results: Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. Conclusions: We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes.
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spelling pubmed-96050532022-10-27 The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review Koimtzis, Georgios Stefanopoulos, Leandros Brooker, Verity Geropoulos, Georgios Chalklin, Christopher G. Gupta, Sapna Carrington-Windo, Eliot Papaioannou, Maria Papavramidis, Theodosios S. Life (Basel) Systematic Review The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Results: Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. Conclusions: We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes. MDPI 2022-10-20 /pmc/articles/PMC9605053/ /pubmed/36295099 http://dx.doi.org/10.3390/life12101664 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Koimtzis, Georgios
Stefanopoulos, Leandros
Brooker, Verity
Geropoulos, Georgios
Chalklin, Christopher G.
Gupta, Sapna
Carrington-Windo, Eliot
Papaioannou, Maria
Papavramidis, Theodosios S.
The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title_full The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title_fullStr The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title_full_unstemmed The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title_short The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
title_sort role of vitamin d in kidney transplantation outcomes: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605053/
https://www.ncbi.nlm.nih.gov/pubmed/36295099
http://dx.doi.org/10.3390/life12101664
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