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The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review
The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605053/ https://www.ncbi.nlm.nih.gov/pubmed/36295099 http://dx.doi.org/10.3390/life12101664 |
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author | Koimtzis, Georgios Stefanopoulos, Leandros Brooker, Verity Geropoulos, Georgios Chalklin, Christopher G. Gupta, Sapna Carrington-Windo, Eliot Papaioannou, Maria Papavramidis, Theodosios S. |
author_facet | Koimtzis, Georgios Stefanopoulos, Leandros Brooker, Verity Geropoulos, Georgios Chalklin, Christopher G. Gupta, Sapna Carrington-Windo, Eliot Papaioannou, Maria Papavramidis, Theodosios S. |
author_sort | Koimtzis, Georgios |
collection | PubMed |
description | The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Results: Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. Conclusions: We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes. |
format | Online Article Text |
id | pubmed-9605053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96050532022-10-27 The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review Koimtzis, Georgios Stefanopoulos, Leandros Brooker, Verity Geropoulos, Georgios Chalklin, Christopher G. Gupta, Sapna Carrington-Windo, Eliot Papaioannou, Maria Papavramidis, Theodosios S. Life (Basel) Systematic Review The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Results: Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. Conclusions: We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes. MDPI 2022-10-20 /pmc/articles/PMC9605053/ /pubmed/36295099 http://dx.doi.org/10.3390/life12101664 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Koimtzis, Georgios Stefanopoulos, Leandros Brooker, Verity Geropoulos, Georgios Chalklin, Christopher G. Gupta, Sapna Carrington-Windo, Eliot Papaioannou, Maria Papavramidis, Theodosios S. The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title | The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title_full | The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title_fullStr | The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title_full_unstemmed | The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title_short | The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review |
title_sort | role of vitamin d in kidney transplantation outcomes: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605053/ https://www.ncbi.nlm.nih.gov/pubmed/36295099 http://dx.doi.org/10.3390/life12101664 |
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