Cargando…

Connecting phenotype to genotype: PheWAS-inspired analysis of autism spectrum disorder

Autism Spectrum Disorder (ASD) is extremely heterogeneous clinically and genetically. There is a pressing need for a better understanding of the heterogeneity of ASD based on scientifically rigorous approaches centered on systematic evaluation of the clinical and research utility of both phenotype a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matta, John, Dobrino, Daniel, Yeboah, Dacosta, Howard, Swade, EL-Manzalawy, Yasser, Obafemi-Ajayi, Tayo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Human Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605200/ https://www.ncbi.nlm.nih.gov/pubmed/36310845 http://dx.doi.org/10.3389/fnhum.2022.960991

Ejemplares similares

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View
por: Pendergrass, Sarah A, et al.
Publicado: (2012)

Realising the full potential of MR-PHeWAS in cancer
por: Bowden, Jack
Publicado: (2020)

Learning Opportunities for Drug Repositioning via GWAS and PheWAS Findings
por: Yin, Wen, et al.
Publicado: (2018)

Biomarker discovery in inflammatory bowel diseases using network-based feature selection
por: Abbas, Mostafa, et al.
Publicado: (2019)

Applications of node-based resilience graph theoretic framework to clustering autism spectrum disorders phenotypes
por: Matta, John, et al.
Publicado: (2018)

Multi-PheWAS intersection approach to identify sex differences across comorbidities in 59 140 pediatric patients with autism spectrum disorder
por: Gutiérrez-Sacristán, Alba, et al.
Publicado: (2021)

PheWAS-Based Systems Genetics Methods for Anti-Breast Cancer Drug Discovery
por: Gao, Min, et al.
Publicado: (2019)

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort
por: Read, Robert W., et al.
Publicado: (2019)

Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach
por: Feng, Yen-Chen A., et al.
Publicado: (2022)

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations
por: Denny, Joshua C., et al.
Publicado: (2010)

Human-Disease Phenotype Map Derived from PheWAS across 38,682 Individuals
por: Verma, Anurag, et al.
Publicado: (2019)

A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank
por: Leppert, Beate, et al.
Publicado: (2020)

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent
por: Li, Longman, et al.
Publicado: (2021)

Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors
por: Hellwege, Jacklyn N., et al.
Publicado: (2023)

A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
por: Zhao, Xueyan, et al.
Publicado: (2019)

Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
por: Khosravi, Ali, et al.
Publicado: (2019)

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging
por: Millard, Louise A. C., et al.
Publicado: (2019)

Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data
por: Nam, Yonghyun, et al.
Publicado: (2022)

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016)

A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations
por: Kim, Seung-Soo, et al.
Publicado: (2021)

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank
por: Zhang, Xiaomeng, et al.
Publicado: (2021)

BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data
por: Kässens, Jan Christian, et al.
Publicado: (2021)

A Case-Crossover Phenome-wide association study (PheWAS) for understanding Post-COVID-19 diagnosis patterns
por: Haupert, Spencer R., et al.
Publicado: (2022)

A phenome-wide association study (PheWAS) to identify the health impacts of 4-cresol sulfate in the Nagahama Study
por: Ou, Huiting, et al.
Publicado: (2023)

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
por: Pendergrass, Sarah A., et al.
Publicado: (2013)

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank
por: Li, Xue, et al.
Publicado: (2018)

netCRS: Network-based comorbidity risk score for prediction of myocardial infarction using biobank-scaled PheWAS data
por: Nam, Yonghyun, et al.
Publicado: (2022)

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders
por: Topaloudi, Apostolia, et al.
Publicado: (2023)

MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization
por: Millard, Louise A. C., et al.
Publicado: (2015)

Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions
por: King, Catherine, et al.
Publicado: (2020)

A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine
por: Salvatore, Maxwell, et al.
Publicado: (2021)

A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine
por: Salvatore, Maxwell, et al.
Publicado: (2021)

Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder
por: Hanaie, Ryuzo, et al.
Publicado: (2018)

Narrowband Resting-State fNIRS Functional Connectivity in Autism Spectrum Disorder
por: Sun, Weiting, et al.
Publicado: (2021)

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
por: Pendergrass, Sarah A., et al.
Publicado: (2019)

Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
por: Meng, Xiangfei, et al.
Publicado: (2022)

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
por: Hall, Molly A., et al.
Publicado: (2014)

Analysis of Brain Functional Connectivity Neural Circuits in Children With Autism Based on Persistent Homology
por: Liang, Di, et al.
Publicado: (2021)

Altered intrinsic brain activity and connectivity in unaffected parents of individuals with autism spectrum disorder: a resting-state fMRI study
por: Zhu, Xiang-Wen, et al.
Publicado: (2022)

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis
por: Namjou, Bahram, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_o8ijem708rcvkp8bsn6ita3elf