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Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma

As an evolutionarily phenotypic conversion program, the epithelial-mesenchymal transition (EMT) has been implicated in tumour deterioration and has facilitated the metastatic ability of cancer cells via enhancing migration and invasion. Gastric cancer (GC) remains a frequently diagnosed non-skin mal...

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Autores principales: Feng, Ying-Nan, Li, Bo-Ya, Wang, Ke, Li, Xiao-Xi, Zhang, Lan, Dong, Xian-Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605205/
https://www.ncbi.nlm.nih.gov/pubmed/36310592
http://dx.doi.org/10.3389/fmolb.2022.977280
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author Feng, Ying-Nan
Li, Bo-Ya
Wang, Ke
Li, Xiao-Xi
Zhang, Lan
Dong, Xian-Zhe
author_facet Feng, Ying-Nan
Li, Bo-Ya
Wang, Ke
Li, Xiao-Xi
Zhang, Lan
Dong, Xian-Zhe
author_sort Feng, Ying-Nan
collection PubMed
description As an evolutionarily phenotypic conversion program, the epithelial-mesenchymal transition (EMT) has been implicated in tumour deterioration and has facilitated the metastatic ability of cancer cells via enhancing migration and invasion. Gastric cancer (GC) remains a frequently diagnosed non-skin malignancy globally. Most GC-associated mortality can be attributed to metastasis. Recent studies have shown that EMT-related long non-coding RNAs (lncRNAs) play a critical role in GC progression and GC cell motility. In addition, lncRNAs are associated with EMT-related transcription factors and signalling pathways. In the present review, we comprehensively described the EMT-inducing lncRNA molecular mechanisms and functional perspectives of EMT-inducing lncRNAs in GC progression. Taken together, the statements of this review provided a clinical implementation in identifying lncRNAs as potential therapeutic targets for advanced GC.
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spelling pubmed-96052052022-10-27 Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma Feng, Ying-Nan Li, Bo-Ya Wang, Ke Li, Xiao-Xi Zhang, Lan Dong, Xian-Zhe Front Mol Biosci Molecular Biosciences As an evolutionarily phenotypic conversion program, the epithelial-mesenchymal transition (EMT) has been implicated in tumour deterioration and has facilitated the metastatic ability of cancer cells via enhancing migration and invasion. Gastric cancer (GC) remains a frequently diagnosed non-skin malignancy globally. Most GC-associated mortality can be attributed to metastasis. Recent studies have shown that EMT-related long non-coding RNAs (lncRNAs) play a critical role in GC progression and GC cell motility. In addition, lncRNAs are associated with EMT-related transcription factors and signalling pathways. In the present review, we comprehensively described the EMT-inducing lncRNA molecular mechanisms and functional perspectives of EMT-inducing lncRNAs in GC progression. Taken together, the statements of this review provided a clinical implementation in identifying lncRNAs as potential therapeutic targets for advanced GC. Frontiers Media S.A. 2022-10-12 /pmc/articles/PMC9605205/ /pubmed/36310592 http://dx.doi.org/10.3389/fmolb.2022.977280 Text en Copyright © 2022 Feng, Li, Wang, Li, Zhang and Dong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Feng, Ying-Nan
Li, Bo-Ya
Wang, Ke
Li, Xiao-Xi
Zhang, Lan
Dong, Xian-Zhe
Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title_full Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title_fullStr Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title_full_unstemmed Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title_short Epithelial-mesenchymal transition-related long noncoding RNAs in gastric carcinoma
title_sort epithelial-mesenchymal transition-related long noncoding rnas in gastric carcinoma
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605205/
https://www.ncbi.nlm.nih.gov/pubmed/36310592
http://dx.doi.org/10.3389/fmolb.2022.977280
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