Cargando…

Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature

Hypertension, as a primary risk factor for many fatal disorders, is prevalent in the elderly. There is wide literature on hypertension dealing with its biological and/or biochemical aspects; however, limited research is available on the multifactorial nature of hypertension from a mechanobiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Taghizadeh, Hadi, Taghizadehghalehjoughi, Ali, Yildirim, Serkan, Ozkaraca, Mustafa, Genc, Sidika, Yeni, Yesim, Mokresh, Muhammed Yasser, Hacimuftuoglu, Ahmet, Tsatsakis, Aristidis, Tsarouhas, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605210/
https://www.ncbi.nlm.nih.gov/pubmed/36294740
http://dx.doi.org/10.3390/jpm12101602
_version_ 1784818008734040064
author Taghizadeh, Hadi
Taghizadehghalehjoughi, Ali
Yildirim, Serkan
Ozkaraca, Mustafa
Genc, Sidika
Yeni, Yesim
Mokresh, Muhammed Yasser
Hacimuftuoglu, Ahmet
Tsatsakis, Aristidis
Tsarouhas, Konstantinos
author_facet Taghizadeh, Hadi
Taghizadehghalehjoughi, Ali
Yildirim, Serkan
Ozkaraca, Mustafa
Genc, Sidika
Yeni, Yesim
Mokresh, Muhammed Yasser
Hacimuftuoglu, Ahmet
Tsatsakis, Aristidis
Tsarouhas, Konstantinos
author_sort Taghizadeh, Hadi
collection PubMed
description Hypertension, as a primary risk factor for many fatal disorders, is prevalent in the elderly. There is wide literature on hypertension dealing with its biological and/or biochemical aspects; however, limited research is available on the multifactorial nature of hypertension from a mechanobiological standpoint. This study intended to study in parallel histopathological alterations and deviated protein expressions with the mechanical behavior of the hypertensive tissues. The Goldblatt (2K1C) method was chosen for induction of renovascular hypertension in rabbits. The microstructural and immunohistological characteristics of the aortic, pancreatic, and brain vasculature were investigated. The mechanical properties of the aortic tissue were also evaluated using biaxial tensile tests. Our findings indicated severe hypertrophy of the hypertensive vessels and declined content of intact smooth muscle cells. Most of the collagen I content of the wall was compromised and less functional type III collagen was highly expressed. Reversed collagen I to collagen III ratio was the main contributor to the hypertrophic and less stiff hypertensive vessel walls. The multifactorial nature of hypertension is illustrated, and smooth muscle cell detachment is identified as the sign of described degenerative cascades all along the arterial tree.
format Online
Article
Text
id pubmed-9605210
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96052102022-10-27 Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature Taghizadeh, Hadi Taghizadehghalehjoughi, Ali Yildirim, Serkan Ozkaraca, Mustafa Genc, Sidika Yeni, Yesim Mokresh, Muhammed Yasser Hacimuftuoglu, Ahmet Tsatsakis, Aristidis Tsarouhas, Konstantinos J Pers Med Article Hypertension, as a primary risk factor for many fatal disorders, is prevalent in the elderly. There is wide literature on hypertension dealing with its biological and/or biochemical aspects; however, limited research is available on the multifactorial nature of hypertension from a mechanobiological standpoint. This study intended to study in parallel histopathological alterations and deviated protein expressions with the mechanical behavior of the hypertensive tissues. The Goldblatt (2K1C) method was chosen for induction of renovascular hypertension in rabbits. The microstructural and immunohistological characteristics of the aortic, pancreatic, and brain vasculature were investigated. The mechanical properties of the aortic tissue were also evaluated using biaxial tensile tests. Our findings indicated severe hypertrophy of the hypertensive vessels and declined content of intact smooth muscle cells. Most of the collagen I content of the wall was compromised and less functional type III collagen was highly expressed. Reversed collagen I to collagen III ratio was the main contributor to the hypertrophic and less stiff hypertensive vessel walls. The multifactorial nature of hypertension is illustrated, and smooth muscle cell detachment is identified as the sign of described degenerative cascades all along the arterial tree. MDPI 2022-09-28 /pmc/articles/PMC9605210/ /pubmed/36294740 http://dx.doi.org/10.3390/jpm12101602 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taghizadeh, Hadi
Taghizadehghalehjoughi, Ali
Yildirim, Serkan
Ozkaraca, Mustafa
Genc, Sidika
Yeni, Yesim
Mokresh, Muhammed Yasser
Hacimuftuoglu, Ahmet
Tsatsakis, Aristidis
Tsarouhas, Konstantinos
Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title_full Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title_fullStr Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title_full_unstemmed Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title_short Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
title_sort deteriorated vascular homeostasis in hypertension: experimental evidence from aorta, brain, and pancreatic vasculature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605210/
https://www.ncbi.nlm.nih.gov/pubmed/36294740
http://dx.doi.org/10.3390/jpm12101602
work_keys_str_mv AT taghizadehhadi deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT taghizadehghalehjoughiali deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT yildirimserkan deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT ozkaracamustafa deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT gencsidika deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT yeniyesim deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT mokreshmuhammedyasser deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT hacimuftuogluahmet deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT tsatsakisaristidis deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature
AT tsarouhaskonstantinos deterioratedvascularhomeostasisinhypertensionexperimentalevidencefromaortabrainandpancreaticvasculature