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The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability
The aim of this study was to assess whether heart rate variability (HRV) could predict which hemisphere of the brain was affected during an acute ischemic stroke (AIS). To achieve this goal, we compared HRV between patients with a right (RH) and left hemispheric (LH) stroke. The studied group consis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605232/ https://www.ncbi.nlm.nih.gov/pubmed/36295094 http://dx.doi.org/10.3390/life12101659 |
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author | Aftyka, Joanna Staszewski, Jacek Dębiec, Aleksander Pogoda-Wesołowska, Aleksandra Kowalska, Agata Jankowska, Anna Żebrowski, Jan |
author_facet | Aftyka, Joanna Staszewski, Jacek Dębiec, Aleksander Pogoda-Wesołowska, Aleksandra Kowalska, Agata Jankowska, Anna Żebrowski, Jan |
author_sort | Aftyka, Joanna |
collection | PubMed |
description | The aim of this study was to assess whether heart rate variability (HRV) could predict which hemisphere of the brain was affected during an acute ischemic stroke (AIS). To achieve this goal, we compared HRV between patients with a right (RH) and left hemispheric (LH) stroke. The studied group consisted of 64 patients with AIS (25 with RH and 39 with LH stroke, with a mean age of 64 ± 12 and 66 ± 13, p = 0.3, respectively) using 24 h Holter ECG records at NN intervals performed at a mean of 4.3 ± 2 days following their AIS. Standard linear methods were used to analyze HRV in the time and frequency domains, as well as nonlinear methods, including sample entropy, detrended fluctuation analysis, and asymmetry measures. Patients with an LH stroke had significantly greater values for sample entropy compared to subjects with an RH stroke (1.31 ± 0.53 vs. 0.92 ± 0.46, p = 0.003, Bonferroni-corrected p = 0.033, effect size = 0.8). The LH stroke group also had higher RMSSD (113 ± 81 vs. 76 ± 61, p = 0.06), pNN50 (33.35 ± 28.54 vs. 18.52 ± 23.75, p = 0.02), and HF(nu) (48.42 ± 16.41 vs. 42.66 ± 17.88, p = 0.11) values, when compared to the RH group, which was possibly related to higher activity in the parasympathetic system in the LH group. Conversely, subjects with RH stroke had higher LF(nu) (57.34 ± 17.88 vs. 51.58 ± 16.41, p-value = 0.11) and LF/HF ratios (2.24 ± 2.87 vs. 1.68 ± 2.50, p-value = 0.11), which were likely related to higher activity in the sympathetic nervous system, when compared to the LH stroke group. Our pilot study demonstrated that patients with RH stroke had lower HRV complexity than those with LH stroke, indicating that HRV could be useful in the discrimination of hemispheric involvement in AIS. |
format | Online Article Text |
id | pubmed-9605232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96052322022-10-27 The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability Aftyka, Joanna Staszewski, Jacek Dębiec, Aleksander Pogoda-Wesołowska, Aleksandra Kowalska, Agata Jankowska, Anna Żebrowski, Jan Life (Basel) Article The aim of this study was to assess whether heart rate variability (HRV) could predict which hemisphere of the brain was affected during an acute ischemic stroke (AIS). To achieve this goal, we compared HRV between patients with a right (RH) and left hemispheric (LH) stroke. The studied group consisted of 64 patients with AIS (25 with RH and 39 with LH stroke, with a mean age of 64 ± 12 and 66 ± 13, p = 0.3, respectively) using 24 h Holter ECG records at NN intervals performed at a mean of 4.3 ± 2 days following their AIS. Standard linear methods were used to analyze HRV in the time and frequency domains, as well as nonlinear methods, including sample entropy, detrended fluctuation analysis, and asymmetry measures. Patients with an LH stroke had significantly greater values for sample entropy compared to subjects with an RH stroke (1.31 ± 0.53 vs. 0.92 ± 0.46, p = 0.003, Bonferroni-corrected p = 0.033, effect size = 0.8). The LH stroke group also had higher RMSSD (113 ± 81 vs. 76 ± 61, p = 0.06), pNN50 (33.35 ± 28.54 vs. 18.52 ± 23.75, p = 0.02), and HF(nu) (48.42 ± 16.41 vs. 42.66 ± 17.88, p = 0.11) values, when compared to the RH group, which was possibly related to higher activity in the parasympathetic system in the LH group. Conversely, subjects with RH stroke had higher LF(nu) (57.34 ± 17.88 vs. 51.58 ± 16.41, p-value = 0.11) and LF/HF ratios (2.24 ± 2.87 vs. 1.68 ± 2.50, p-value = 0.11), which were likely related to higher activity in the sympathetic nervous system, when compared to the LH stroke group. Our pilot study demonstrated that patients with RH stroke had lower HRV complexity than those with LH stroke, indicating that HRV could be useful in the discrimination of hemispheric involvement in AIS. MDPI 2022-10-20 /pmc/articles/PMC9605232/ /pubmed/36295094 http://dx.doi.org/10.3390/life12101659 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aftyka, Joanna Staszewski, Jacek Dębiec, Aleksander Pogoda-Wesołowska, Aleksandra Kowalska, Agata Jankowska, Anna Żebrowski, Jan The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title | The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title_full | The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title_fullStr | The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title_full_unstemmed | The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title_short | The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability |
title_sort | hemisphere of the brain in which a stroke has occurred visible in the heart rate variability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605232/ https://www.ncbi.nlm.nih.gov/pubmed/36295094 http://dx.doi.org/10.3390/life12101659 |
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