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Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation

Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive...

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Detalles Bibliográficos
Autores principales: Kheifets, Mark, Angelini, Filippo, D’Ascenzo, Fabrizio, Pidello, Stefano, Engelstein, Haya, Bocchino, Pier Paolo, Boretto, Paolo, Frea, Simone, Levi, Amos, Vaknin-Assa, Hana, Vaturi, Mordehay, Shapira, Yaron, Kornowski, Ran, Perl, Leor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605257/
https://www.ncbi.nlm.nih.gov/pubmed/36294332
http://dx.doi.org/10.3390/jcm11206010
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author Kheifets, Mark
Angelini, Filippo
D’Ascenzo, Fabrizio
Pidello, Stefano
Engelstein, Haya
Bocchino, Pier Paolo
Boretto, Paolo
Frea, Simone
Levi, Amos
Vaknin-Assa, Hana
Vaturi, Mordehay
Shapira, Yaron
Kornowski, Ran
Perl, Leor
author_facet Kheifets, Mark
Angelini, Filippo
D’Ascenzo, Fabrizio
Pidello, Stefano
Engelstein, Haya
Bocchino, Pier Paolo
Boretto, Paolo
Frea, Simone
Levi, Amos
Vaknin-Assa, Hana
Vaturi, Mordehay
Shapira, Yaron
Kornowski, Ran
Perl, Leor
author_sort Kheifets, Mark
collection PubMed
description Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive patients who underwent TEER over a ten-year period were analyzed. Primary endpoints included rates of all-cause death and major adverse cardiac events (MACE: composite of all-cause death, hospitalizations for heart failure, mitral valve surgery, or TEER re-intervention). A total of 148 (71%) patients were identified with FMR, while 60 (29%) were identified with DMR. Patients in the FMR group were younger (77.2 ± 8.4 vs. 80.2 ± 7.2, p = 0.02), suffered more frequently from coronary artery disease (54.1% vs. 10.0%, p = 0.02), and atrial fibrillation/flutter (70.9% vs. 38.3%, p = 0.02). Rates of 1-year death (21.6% vs. 10.0%, p = 0.03) and MACE (41.2% vs. 21.7%, p = 0.02) were higher for the FMR group, as compared to the DMR group. After correcting for variables, FMR independently predicted rates of MACE (HR-1.78, 95% CI 1.23–2.48, p = 0.04) and had a non-significant effect on one-year mortality (HR-1.67, 95%CI 0.98–3.74, p = 0.07). In our experience, worse overall 1-year composite MACE outcomes were observed after TEER in patients with FMR as compared to patients with DMR.
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spelling pubmed-96052572022-10-27 Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation Kheifets, Mark Angelini, Filippo D’Ascenzo, Fabrizio Pidello, Stefano Engelstein, Haya Bocchino, Pier Paolo Boretto, Paolo Frea, Simone Levi, Amos Vaknin-Assa, Hana Vaturi, Mordehay Shapira, Yaron Kornowski, Ran Perl, Leor J Clin Med Article Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive patients who underwent TEER over a ten-year period were analyzed. Primary endpoints included rates of all-cause death and major adverse cardiac events (MACE: composite of all-cause death, hospitalizations for heart failure, mitral valve surgery, or TEER re-intervention). A total of 148 (71%) patients were identified with FMR, while 60 (29%) were identified with DMR. Patients in the FMR group were younger (77.2 ± 8.4 vs. 80.2 ± 7.2, p = 0.02), suffered more frequently from coronary artery disease (54.1% vs. 10.0%, p = 0.02), and atrial fibrillation/flutter (70.9% vs. 38.3%, p = 0.02). Rates of 1-year death (21.6% vs. 10.0%, p = 0.03) and MACE (41.2% vs. 21.7%, p = 0.02) were higher for the FMR group, as compared to the DMR group. After correcting for variables, FMR independently predicted rates of MACE (HR-1.78, 95% CI 1.23–2.48, p = 0.04) and had a non-significant effect on one-year mortality (HR-1.67, 95%CI 0.98–3.74, p = 0.07). In our experience, worse overall 1-year composite MACE outcomes were observed after TEER in patients with FMR as compared to patients with DMR. MDPI 2022-10-12 /pmc/articles/PMC9605257/ /pubmed/36294332 http://dx.doi.org/10.3390/jcm11206010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kheifets, Mark
Angelini, Filippo
D’Ascenzo, Fabrizio
Pidello, Stefano
Engelstein, Haya
Bocchino, Pier Paolo
Boretto, Paolo
Frea, Simone
Levi, Amos
Vaknin-Assa, Hana
Vaturi, Mordehay
Shapira, Yaron
Kornowski, Ran
Perl, Leor
Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title_full Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title_fullStr Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title_full_unstemmed Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title_short Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
title_sort outcomes of transcatheter edge-to-edge repair in degenerative vs. functional mitral regurgitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605257/
https://www.ncbi.nlm.nih.gov/pubmed/36294332
http://dx.doi.org/10.3390/jcm11206010
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