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Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation
Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605257/ https://www.ncbi.nlm.nih.gov/pubmed/36294332 http://dx.doi.org/10.3390/jcm11206010 |
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author | Kheifets, Mark Angelini, Filippo D’Ascenzo, Fabrizio Pidello, Stefano Engelstein, Haya Bocchino, Pier Paolo Boretto, Paolo Frea, Simone Levi, Amos Vaknin-Assa, Hana Vaturi, Mordehay Shapira, Yaron Kornowski, Ran Perl, Leor |
author_facet | Kheifets, Mark Angelini, Filippo D’Ascenzo, Fabrizio Pidello, Stefano Engelstein, Haya Bocchino, Pier Paolo Boretto, Paolo Frea, Simone Levi, Amos Vaknin-Assa, Hana Vaturi, Mordehay Shapira, Yaron Kornowski, Ran Perl, Leor |
author_sort | Kheifets, Mark |
collection | PubMed |
description | Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive patients who underwent TEER over a ten-year period were analyzed. Primary endpoints included rates of all-cause death and major adverse cardiac events (MACE: composite of all-cause death, hospitalizations for heart failure, mitral valve surgery, or TEER re-intervention). A total of 148 (71%) patients were identified with FMR, while 60 (29%) were identified with DMR. Patients in the FMR group were younger (77.2 ± 8.4 vs. 80.2 ± 7.2, p = 0.02), suffered more frequently from coronary artery disease (54.1% vs. 10.0%, p = 0.02), and atrial fibrillation/flutter (70.9% vs. 38.3%, p = 0.02). Rates of 1-year death (21.6% vs. 10.0%, p = 0.03) and MACE (41.2% vs. 21.7%, p = 0.02) were higher for the FMR group, as compared to the DMR group. After correcting for variables, FMR independently predicted rates of MACE (HR-1.78, 95% CI 1.23–2.48, p = 0.04) and had a non-significant effect on one-year mortality (HR-1.67, 95%CI 0.98–3.74, p = 0.07). In our experience, worse overall 1-year composite MACE outcomes were observed after TEER in patients with FMR as compared to patients with DMR. |
format | Online Article Text |
id | pubmed-9605257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96052572022-10-27 Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation Kheifets, Mark Angelini, Filippo D’Ascenzo, Fabrizio Pidello, Stefano Engelstein, Haya Bocchino, Pier Paolo Boretto, Paolo Frea, Simone Levi, Amos Vaknin-Assa, Hana Vaturi, Mordehay Shapira, Yaron Kornowski, Ran Perl, Leor J Clin Med Article Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive patients who underwent TEER over a ten-year period were analyzed. Primary endpoints included rates of all-cause death and major adverse cardiac events (MACE: composite of all-cause death, hospitalizations for heart failure, mitral valve surgery, or TEER re-intervention). A total of 148 (71%) patients were identified with FMR, while 60 (29%) were identified with DMR. Patients in the FMR group were younger (77.2 ± 8.4 vs. 80.2 ± 7.2, p = 0.02), suffered more frequently from coronary artery disease (54.1% vs. 10.0%, p = 0.02), and atrial fibrillation/flutter (70.9% vs. 38.3%, p = 0.02). Rates of 1-year death (21.6% vs. 10.0%, p = 0.03) and MACE (41.2% vs. 21.7%, p = 0.02) were higher for the FMR group, as compared to the DMR group. After correcting for variables, FMR independently predicted rates of MACE (HR-1.78, 95% CI 1.23–2.48, p = 0.04) and had a non-significant effect on one-year mortality (HR-1.67, 95%CI 0.98–3.74, p = 0.07). In our experience, worse overall 1-year composite MACE outcomes were observed after TEER in patients with FMR as compared to patients with DMR. MDPI 2022-10-12 /pmc/articles/PMC9605257/ /pubmed/36294332 http://dx.doi.org/10.3390/jcm11206010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kheifets, Mark Angelini, Filippo D’Ascenzo, Fabrizio Pidello, Stefano Engelstein, Haya Bocchino, Pier Paolo Boretto, Paolo Frea, Simone Levi, Amos Vaknin-Assa, Hana Vaturi, Mordehay Shapira, Yaron Kornowski, Ran Perl, Leor Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title | Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title_full | Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title_fullStr | Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title_full_unstemmed | Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title_short | Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation |
title_sort | outcomes of transcatheter edge-to-edge repair in degenerative vs. functional mitral regurgitation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605257/ https://www.ncbi.nlm.nih.gov/pubmed/36294332 http://dx.doi.org/10.3390/jcm11206010 |
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