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Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology

Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In the present study, we followed a suprasystolic reactive hyperemia (RH) maneuver with a multi-spectral optoacoustic tomography (MSOT) syste...

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Autores principales: Monteiro Rodrigues, Luis, Granja, Tiago F., de Andrade, Sergio Faloni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605317/
https://www.ncbi.nlm.nih.gov/pubmed/36295063
http://dx.doi.org/10.3390/life12101628
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author Monteiro Rodrigues, Luis
Granja, Tiago F.
de Andrade, Sergio Faloni
author_facet Monteiro Rodrigues, Luis
Granja, Tiago F.
de Andrade, Sergio Faloni
author_sort Monteiro Rodrigues, Luis
collection PubMed
description Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In the present study, we followed a suprasystolic reactive hyperemia (RH) maneuver with a multi-spectral optoacoustic tomography (MSOT) system. A convenience sample of ten participants, both sexes, mean age of 35.8 ± 13.3 years old, was selected. All procedures were in accordance with the principles of good clinical practice and approved by the institutional ethics committee. Images were obtained at baseline (resting), during occlusion, and immediately after pressure release. Observations of the RH by PAT identified superficial and deeper vascular structures parallel to the skin surface as part of the human skin vascular plexus. Furthermore, PAT revealed that the suprasystolic occlusion impacts both plexus differently, practically obliterating the superficial smaller vessels and evoking stasis at the deeper, larger structures in real-time (live) conditions. This dual effect of RH on the skin plexus has not been explored and is not considered in clinical settings. Thus, RH seems to represent much more than the local microvascular reperfusion as typically described, and PAT offers a vast potential for vascular clinical and preclinical research.
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spelling pubmed-96053172022-10-27 Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology Monteiro Rodrigues, Luis Granja, Tiago F. de Andrade, Sergio Faloni Life (Basel) Article Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In the present study, we followed a suprasystolic reactive hyperemia (RH) maneuver with a multi-spectral optoacoustic tomography (MSOT) system. A convenience sample of ten participants, both sexes, mean age of 35.8 ± 13.3 years old, was selected. All procedures were in accordance with the principles of good clinical practice and approved by the institutional ethics committee. Images were obtained at baseline (resting), during occlusion, and immediately after pressure release. Observations of the RH by PAT identified superficial and deeper vascular structures parallel to the skin surface as part of the human skin vascular plexus. Furthermore, PAT revealed that the suprasystolic occlusion impacts both plexus differently, practically obliterating the superficial smaller vessels and evoking stasis at the deeper, larger structures in real-time (live) conditions. This dual effect of RH on the skin plexus has not been explored and is not considered in clinical settings. Thus, RH seems to represent much more than the local microvascular reperfusion as typically described, and PAT offers a vast potential for vascular clinical and preclinical research. MDPI 2022-10-18 /pmc/articles/PMC9605317/ /pubmed/36295063 http://dx.doi.org/10.3390/life12101628 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monteiro Rodrigues, Luis
Granja, Tiago F.
de Andrade, Sergio Faloni
Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title_full Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title_fullStr Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title_full_unstemmed Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title_short Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
title_sort optoacoustic imaging offers new insights into in vivo human skin vascular physiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605317/
https://www.ncbi.nlm.nih.gov/pubmed/36295063
http://dx.doi.org/10.3390/life12101628
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