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Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605318/ https://www.ncbi.nlm.nih.gov/pubmed/36294756 http://dx.doi.org/10.3390/jpm12101616 |
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author | Sergi, Bruno Settimi, Stefano Federici, Gaia Galloni, Costanza Cantaffa, Carla De Corso, Eugenio Lucidi, Daniela |
author_facet | Sergi, Bruno Settimi, Stefano Federici, Gaia Galloni, Costanza Cantaffa, Carla De Corso, Eugenio Lucidi, Daniela |
author_sort | Sergi, Bruno |
collection | PubMed |
description | Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different therapeutic choices, with a view to a personalized VS approach. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between February and March 2022. The authors defined six parameters that seemed to influence decision-making in VS management: 1-incidental VS; 2-tumor size; 3-tumor regrowth after sRT; 4-subtotal resection; 5-patients’ age; 6-symptoms. The initial search yielded 3532 articles, and finally, 812 articles were included. Through a qualitative synthesis of the included studies, management strategies were evaluated and discussed. An individualized proposal of procedures is preferable as compared to a single gold-standard approach in VS decision-making. The most significant factors that need to be considered when dealing with a VS diagnosis are age, tumor size and hearing preservation issues. |
format | Online Article Text |
id | pubmed-9605318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96053182022-10-27 Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review Sergi, Bruno Settimi, Stefano Federici, Gaia Galloni, Costanza Cantaffa, Carla De Corso, Eugenio Lucidi, Daniela J Pers Med Review Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different therapeutic choices, with a view to a personalized VS approach. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between February and March 2022. The authors defined six parameters that seemed to influence decision-making in VS management: 1-incidental VS; 2-tumor size; 3-tumor regrowth after sRT; 4-subtotal resection; 5-patients’ age; 6-symptoms. The initial search yielded 3532 articles, and finally, 812 articles were included. Through a qualitative synthesis of the included studies, management strategies were evaluated and discussed. An individualized proposal of procedures is preferable as compared to a single gold-standard approach in VS decision-making. The most significant factors that need to be considered when dealing with a VS diagnosis are age, tumor size and hearing preservation issues. MDPI 2022-09-30 /pmc/articles/PMC9605318/ /pubmed/36294756 http://dx.doi.org/10.3390/jpm12101616 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sergi, Bruno Settimi, Stefano Federici, Gaia Galloni, Costanza Cantaffa, Carla De Corso, Eugenio Lucidi, Daniela Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title | Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title_full | Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title_fullStr | Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title_full_unstemmed | Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title_short | Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review |
title_sort | factors influencing personalized management of vestibular schwannoma: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605318/ https://www.ncbi.nlm.nih.gov/pubmed/36294756 http://dx.doi.org/10.3390/jpm12101616 |
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