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Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review

Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different th...

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Autores principales: Sergi, Bruno, Settimi, Stefano, Federici, Gaia, Galloni, Costanza, Cantaffa, Carla, De Corso, Eugenio, Lucidi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605318/
https://www.ncbi.nlm.nih.gov/pubmed/36294756
http://dx.doi.org/10.3390/jpm12101616
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author Sergi, Bruno
Settimi, Stefano
Federici, Gaia
Galloni, Costanza
Cantaffa, Carla
De Corso, Eugenio
Lucidi, Daniela
author_facet Sergi, Bruno
Settimi, Stefano
Federici, Gaia
Galloni, Costanza
Cantaffa, Carla
De Corso, Eugenio
Lucidi, Daniela
author_sort Sergi, Bruno
collection PubMed
description Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different therapeutic choices, with a view to a personalized VS approach. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between February and March 2022. The authors defined six parameters that seemed to influence decision-making in VS management: 1-incidental VS; 2-tumor size; 3-tumor regrowth after sRT; 4-subtotal resection; 5-patients’ age; 6-symptoms. The initial search yielded 3532 articles, and finally, 812 articles were included. Through a qualitative synthesis of the included studies, management strategies were evaluated and discussed. An individualized proposal of procedures is preferable as compared to a single gold-standard approach in VS decision-making. The most significant factors that need to be considered when dealing with a VS diagnosis are age, tumor size and hearing preservation issues.
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spelling pubmed-96053182022-10-27 Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review Sergi, Bruno Settimi, Stefano Federici, Gaia Galloni, Costanza Cantaffa, Carla De Corso, Eugenio Lucidi, Daniela J Pers Med Review Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different therapeutic choices, with a view to a personalized VS approach. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between February and March 2022. The authors defined six parameters that seemed to influence decision-making in VS management: 1-incidental VS; 2-tumor size; 3-tumor regrowth after sRT; 4-subtotal resection; 5-patients’ age; 6-symptoms. The initial search yielded 3532 articles, and finally, 812 articles were included. Through a qualitative synthesis of the included studies, management strategies were evaluated and discussed. An individualized proposal of procedures is preferable as compared to a single gold-standard approach in VS decision-making. The most significant factors that need to be considered when dealing with a VS diagnosis are age, tumor size and hearing preservation issues. MDPI 2022-09-30 /pmc/articles/PMC9605318/ /pubmed/36294756 http://dx.doi.org/10.3390/jpm12101616 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sergi, Bruno
Settimi, Stefano
Federici, Gaia
Galloni, Costanza
Cantaffa, Carla
De Corso, Eugenio
Lucidi, Daniela
Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title_full Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title_fullStr Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title_full_unstemmed Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title_short Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review
title_sort factors influencing personalized management of vestibular schwannoma: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605318/
https://www.ncbi.nlm.nih.gov/pubmed/36294756
http://dx.doi.org/10.3390/jpm12101616
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