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Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing
Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in precision oncology. The wide range of actionable molecular alterations in non-squamous non-small cell lung carcinoma (NS-NSCLC) and the multiplicity of mechanisms of resistance to treatment resulted in the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605324/ https://www.ncbi.nlm.nih.gov/pubmed/36294823 http://dx.doi.org/10.3390/jpm12101684 |
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author | Pujol, Nina Heeke, Simon Bontoux, Christophe Boutros, Jacques Ilié, Marius Hofman, Véronique Marquette, Charles-Hugo Hofman, Paul Benzaquen, Jonathan |
author_facet | Pujol, Nina Heeke, Simon Bontoux, Christophe Boutros, Jacques Ilié, Marius Hofman, Véronique Marquette, Charles-Hugo Hofman, Paul Benzaquen, Jonathan |
author_sort | Pujol, Nina |
collection | PubMed |
description | Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in precision oncology. The wide range of actionable molecular alterations in non-squamous non-small cell lung carcinoma (NS-NSCLC) and the multiplicity of mechanisms of resistance to treatment resulted in the need for repeated testing to establish an accurate molecular diagnosis, as well as to track disease evolution over time. While assessing the increasing complexity of the molecular composition of tumors at baseline, as well as over time, has become increasingly challenging, the emergence and implementation of next-generation sequencing (NGS) testing has extensively facilitated molecular profiling in NS-NSCLC. In this review, we discuss recent developments in the molecular profiling of NS-NSCLC and how NGS addresses current needs, as well as how it can be implemented to address future challenges in the management of NS-NSCLC. |
format | Online Article Text |
id | pubmed-9605324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96053242022-10-27 Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing Pujol, Nina Heeke, Simon Bontoux, Christophe Boutros, Jacques Ilié, Marius Hofman, Véronique Marquette, Charles-Hugo Hofman, Paul Benzaquen, Jonathan J Pers Med Review Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in precision oncology. The wide range of actionable molecular alterations in non-squamous non-small cell lung carcinoma (NS-NSCLC) and the multiplicity of mechanisms of resistance to treatment resulted in the need for repeated testing to establish an accurate molecular diagnosis, as well as to track disease evolution over time. While assessing the increasing complexity of the molecular composition of tumors at baseline, as well as over time, has become increasingly challenging, the emergence and implementation of next-generation sequencing (NGS) testing has extensively facilitated molecular profiling in NS-NSCLC. In this review, we discuss recent developments in the molecular profiling of NS-NSCLC and how NGS addresses current needs, as well as how it can be implemented to address future challenges in the management of NS-NSCLC. MDPI 2022-10-09 /pmc/articles/PMC9605324/ /pubmed/36294823 http://dx.doi.org/10.3390/jpm12101684 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pujol, Nina Heeke, Simon Bontoux, Christophe Boutros, Jacques Ilié, Marius Hofman, Véronique Marquette, Charles-Hugo Hofman, Paul Benzaquen, Jonathan Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title | Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title_full | Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title_fullStr | Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title_full_unstemmed | Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title_short | Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing |
title_sort | molecular profiling in non-squamous non-small cell lung carcinoma: towards a switch to next-generation sequencing reflex testing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605324/ https://www.ncbi.nlm.nih.gov/pubmed/36294823 http://dx.doi.org/10.3390/jpm12101684 |
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