Cargando…

Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus

Background: The relevance of drusen-like deposits (DLD) in patients with systemic lupus erythematosus (SLE) is to a large extent uncertain. Their genesis is proposed to be correlated to immune-complex and complement depositions in the framework of SLE. The intention of this study was to determine po...

Descripción completa

Detalles Bibliográficos
Autores principales: Kukan, Marc, Driban, Matthew, Vupparaboina, Kiran K., Schwarz, Swen, Kitay, Alice M., Rasheed, Mohammed A., Busch, Catharina, Barthelmes, Daniel, Chhablani, Jay, Al-Sheikh, Mayss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605325/
https://www.ncbi.nlm.nih.gov/pubmed/36294333
http://dx.doi.org/10.3390/jcm11206012
_version_ 1784818039001186304
author Kukan, Marc
Driban, Matthew
Vupparaboina, Kiran K.
Schwarz, Swen
Kitay, Alice M.
Rasheed, Mohammed A.
Busch, Catharina
Barthelmes, Daniel
Chhablani, Jay
Al-Sheikh, Mayss
author_facet Kukan, Marc
Driban, Matthew
Vupparaboina, Kiran K.
Schwarz, Swen
Kitay, Alice M.
Rasheed, Mohammed A.
Busch, Catharina
Barthelmes, Daniel
Chhablani, Jay
Al-Sheikh, Mayss
author_sort Kukan, Marc
collection PubMed
description Background: The relevance of drusen-like deposits (DLD) in patients with systemic lupus erythematosus (SLE) is to a large extent uncertain. Their genesis is proposed to be correlated to immune-complex and complement depositions in the framework of SLE. The intention of this study was to determine potential morphological differences in the choroid and retina as well as potential microvascular changes comparing two cohorts of SLE patients divergent in the presence or absence of DLD using multimodal imaging. Methods: Both eyes of 16 SLE patients with DLD were compared to an age- and sex-matched control-group consisting of 16 SLE patients without detectable DLD. Both cohorts were treated with hydroxychloroquine (HCQ) and did not differ in the treatment duration or dosage. Using spectral-domain optical coherence tomography (SD-OCT) choroidal volume measures, choroidal vascularity indices (CVI) and retinal layer segmentation was performed and compared. In addition, by the exploitation of optical coherence tomography angiography vascular density, perfusion density of superficial and deep retinal capillary plexuses and the choriocapillaris were analyzed. For the choroidal OCT-scans, a subset of 51 healthy individuals served as a reference-group. Results: CVI measures revealed a significant reduction in eyes with DLD compared to healthy controls (0.56 (0.54–0.59) versus 0.58 (0.57–0.59) (p = 0.018) and 0.56 (0.54–0.58) versus 0.58 (0.57–0.60) (p < 0.001)). The photoreceptor cell layer presented significant thinning in both eyes of subjects with DLD compared to control subjects without DLD (68.8 ± 7.7 µm vs. 77.1 ± 7.3 µm for right eyes, p = 0.008, and 66.5 ± 10.5 µm vs. 76.1 ± 6.3 µm for left eyes, p = 0.011). OCTA scans revealed no significant changes, yet there could be observed numerically lower values in the capillary plexuses of the retina in eyes with DLD than in eyes without DLD. Conclusions: Our results illustrated significant alterations in the choroidal and retinal analyzes, suggesting a correlation between DLD and the progression of inflammatory processes in the course of SLE leading to retinal degeneration. For this reason, DLD could serve as a biomarker for a more active state of disease.
format Online
Article
Text
id pubmed-9605325
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96053252022-10-27 Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus Kukan, Marc Driban, Matthew Vupparaboina, Kiran K. Schwarz, Swen Kitay, Alice M. Rasheed, Mohammed A. Busch, Catharina Barthelmes, Daniel Chhablani, Jay Al-Sheikh, Mayss J Clin Med Article Background: The relevance of drusen-like deposits (DLD) in patients with systemic lupus erythematosus (SLE) is to a large extent uncertain. Their genesis is proposed to be correlated to immune-complex and complement depositions in the framework of SLE. The intention of this study was to determine potential morphological differences in the choroid and retina as well as potential microvascular changes comparing two cohorts of SLE patients divergent in the presence or absence of DLD using multimodal imaging. Methods: Both eyes of 16 SLE patients with DLD were compared to an age- and sex-matched control-group consisting of 16 SLE patients without detectable DLD. Both cohorts were treated with hydroxychloroquine (HCQ) and did not differ in the treatment duration or dosage. Using spectral-domain optical coherence tomography (SD-OCT) choroidal volume measures, choroidal vascularity indices (CVI) and retinal layer segmentation was performed and compared. In addition, by the exploitation of optical coherence tomography angiography vascular density, perfusion density of superficial and deep retinal capillary plexuses and the choriocapillaris were analyzed. For the choroidal OCT-scans, a subset of 51 healthy individuals served as a reference-group. Results: CVI measures revealed a significant reduction in eyes with DLD compared to healthy controls (0.56 (0.54–0.59) versus 0.58 (0.57–0.59) (p = 0.018) and 0.56 (0.54–0.58) versus 0.58 (0.57–0.60) (p < 0.001)). The photoreceptor cell layer presented significant thinning in both eyes of subjects with DLD compared to control subjects without DLD (68.8 ± 7.7 µm vs. 77.1 ± 7.3 µm for right eyes, p = 0.008, and 66.5 ± 10.5 µm vs. 76.1 ± 6.3 µm for left eyes, p = 0.011). OCTA scans revealed no significant changes, yet there could be observed numerically lower values in the capillary plexuses of the retina in eyes with DLD than in eyes without DLD. Conclusions: Our results illustrated significant alterations in the choroidal and retinal analyzes, suggesting a correlation between DLD and the progression of inflammatory processes in the course of SLE leading to retinal degeneration. For this reason, DLD could serve as a biomarker for a more active state of disease. MDPI 2022-10-12 /pmc/articles/PMC9605325/ /pubmed/36294333 http://dx.doi.org/10.3390/jcm11206012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kukan, Marc
Driban, Matthew
Vupparaboina, Kiran K.
Schwarz, Swen
Kitay, Alice M.
Rasheed, Mohammed A.
Busch, Catharina
Barthelmes, Daniel
Chhablani, Jay
Al-Sheikh, Mayss
Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title_full Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title_fullStr Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title_full_unstemmed Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title_short Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus
title_sort structural features of patients with drusen-like deposits and systemic lupus erythematosus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605325/
https://www.ncbi.nlm.nih.gov/pubmed/36294333
http://dx.doi.org/10.3390/jcm11206012
work_keys_str_mv AT kukanmarc structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT dribanmatthew structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT vupparaboinakirank structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT schwarzswen structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT kitayalicem structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT rasheedmohammeda structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT buschcatharina structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT barthelmesdaniel structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT chhablanijay structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus
AT alsheikhmayss structuralfeaturesofpatientswithdrusenlikedepositsandsystemiclupuserythematosus