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Heat Shock Protein 70 and 90 Family in Prostate Cancer
Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605364/ https://www.ncbi.nlm.nih.gov/pubmed/36294924 http://dx.doi.org/10.3390/life12101489 |
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author | Fu, Xun Liu, Jiang Yan, Xin DiSanto, Michael E. Zhang, Xinhua |
author_facet | Fu, Xun Liu, Jiang Yan, Xin DiSanto, Michael E. Zhang, Xinhua |
author_sort | Fu, Xun |
collection | PubMed |
description | Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellular level, HSP molecules have a strong relationship with multiple important biological processes, such as cell differentiation, epithelial–mesenchymal transition (EMT), and fibrosis. Because of the facilitation of HSP family molecules on tumorigenesis, a number of agents and inhibitors are being developed with potent antitumor effects whose target site is the critical structure of HSP molecules. Among all target molecules, HSP70 family and HSP90 are two groups that have been well studied, and therefore, the development of their inhibitors makes great progress. Only a small number of agents, however, have been clinically tested in recruited patients. As a result, more clinical studies are warranted for the establishment of the relationship between the HSP70 family, alongside the HSP90 molecule, and prostate cancer treatment. |
format | Online Article Text |
id | pubmed-9605364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96053642022-10-27 Heat Shock Protein 70 and 90 Family in Prostate Cancer Fu, Xun Liu, Jiang Yan, Xin DiSanto, Michael E. Zhang, Xinhua Life (Basel) Review Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellular level, HSP molecules have a strong relationship with multiple important biological processes, such as cell differentiation, epithelial–mesenchymal transition (EMT), and fibrosis. Because of the facilitation of HSP family molecules on tumorigenesis, a number of agents and inhibitors are being developed with potent antitumor effects whose target site is the critical structure of HSP molecules. Among all target molecules, HSP70 family and HSP90 are two groups that have been well studied, and therefore, the development of their inhibitors makes great progress. Only a small number of agents, however, have been clinically tested in recruited patients. As a result, more clinical studies are warranted for the establishment of the relationship between the HSP70 family, alongside the HSP90 molecule, and prostate cancer treatment. MDPI 2022-09-26 /pmc/articles/PMC9605364/ /pubmed/36294924 http://dx.doi.org/10.3390/life12101489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fu, Xun Liu, Jiang Yan, Xin DiSanto, Michael E. Zhang, Xinhua Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title | Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title_full | Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title_fullStr | Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title_full_unstemmed | Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title_short | Heat Shock Protein 70 and 90 Family in Prostate Cancer |
title_sort | heat shock protein 70 and 90 family in prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605364/ https://www.ncbi.nlm.nih.gov/pubmed/36294924 http://dx.doi.org/10.3390/life12101489 |
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