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Heat Shock Protein 70 and 90 Family in Prostate Cancer

Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellula...

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Detalles Bibliográficos
Autores principales: Fu, Xun, Liu, Jiang, Yan, Xin, DiSanto, Michael E., Zhang, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605364/
https://www.ncbi.nlm.nih.gov/pubmed/36294924
http://dx.doi.org/10.3390/life12101489
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author Fu, Xun
Liu, Jiang
Yan, Xin
DiSanto, Michael E.
Zhang, Xinhua
author_facet Fu, Xun
Liu, Jiang
Yan, Xin
DiSanto, Michael E.
Zhang, Xinhua
author_sort Fu, Xun
collection PubMed
description Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellular level, HSP molecules have a strong relationship with multiple important biological processes, such as cell differentiation, epithelial–mesenchymal transition (EMT), and fibrosis. Because of the facilitation of HSP family molecules on tumorigenesis, a number of agents and inhibitors are being developed with potent antitumor effects whose target site is the critical structure of HSP molecules. Among all target molecules, HSP70 family and HSP90 are two groups that have been well studied, and therefore, the development of their inhibitors makes great progress. Only a small number of agents, however, have been clinically tested in recruited patients. As a result, more clinical studies are warranted for the establishment of the relationship between the HSP70 family, alongside the HSP90 molecule, and prostate cancer treatment.
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spelling pubmed-96053642022-10-27 Heat Shock Protein 70 and 90 Family in Prostate Cancer Fu, Xun Liu, Jiang Yan, Xin DiSanto, Michael E. Zhang, Xinhua Life (Basel) Review Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellular level, HSP molecules have a strong relationship with multiple important biological processes, such as cell differentiation, epithelial–mesenchymal transition (EMT), and fibrosis. Because of the facilitation of HSP family molecules on tumorigenesis, a number of agents and inhibitors are being developed with potent antitumor effects whose target site is the critical structure of HSP molecules. Among all target molecules, HSP70 family and HSP90 are two groups that have been well studied, and therefore, the development of their inhibitors makes great progress. Only a small number of agents, however, have been clinically tested in recruited patients. As a result, more clinical studies are warranted for the establishment of the relationship between the HSP70 family, alongside the HSP90 molecule, and prostate cancer treatment. MDPI 2022-09-26 /pmc/articles/PMC9605364/ /pubmed/36294924 http://dx.doi.org/10.3390/life12101489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fu, Xun
Liu, Jiang
Yan, Xin
DiSanto, Michael E.
Zhang, Xinhua
Heat Shock Protein 70 and 90 Family in Prostate Cancer
title Heat Shock Protein 70 and 90 Family in Prostate Cancer
title_full Heat Shock Protein 70 and 90 Family in Prostate Cancer
title_fullStr Heat Shock Protein 70 and 90 Family in Prostate Cancer
title_full_unstemmed Heat Shock Protein 70 and 90 Family in Prostate Cancer
title_short Heat Shock Protein 70 and 90 Family in Prostate Cancer
title_sort heat shock protein 70 and 90 family in prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605364/
https://www.ncbi.nlm.nih.gov/pubmed/36294924
http://dx.doi.org/10.3390/life12101489
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