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Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis

In patients with acutely changing kidney function, equations used to estimate glomerular filtration rate (eGFR) must be adjusted for dynamic changes in the concentrations of filtration markers (kinetic eGFR, KeGFR). The aim of our study was to evaluate serum creatinine-based KeGFR in patients in the...

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Autores principales: Dumnicka, Paulina, Mazur-Laskowska, Małgorzata, Ceranowicz, Piotr, Sporek, Mateusz, Kolber, Witold, Tisończyk, Joanna, Kuźniewski, Marek, Maziarz, Barbara, Kuśnierz-Cabala, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605446/
https://www.ncbi.nlm.nih.gov/pubmed/36294481
http://dx.doi.org/10.3390/jcm11206159
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author Dumnicka, Paulina
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Sporek, Mateusz
Kolber, Witold
Tisończyk, Joanna
Kuźniewski, Marek
Maziarz, Barbara
Kuśnierz-Cabala, Beata
author_facet Dumnicka, Paulina
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Sporek, Mateusz
Kolber, Witold
Tisończyk, Joanna
Kuźniewski, Marek
Maziarz, Barbara
Kuśnierz-Cabala, Beata
author_sort Dumnicka, Paulina
collection PubMed
description In patients with acutely changing kidney function, equations used to estimate glomerular filtration rate (eGFR) must be adjusted for dynamic changes in the concentrations of filtration markers (kinetic eGFR, KeGFR). The aim of our study was to evaluate serum creatinine-based KeGFR in patients in the early phase of acute pancreatitis (AP) as a marker of changing renal function and as a predictor of AP severity. We retrospectively calculated KeGFR on day 2 and 3 of the hospital stay in a group of 147 adult patients admitted within 24 h from the onset of AP symptoms and treated in two secondary-care hospitals. In 34 (23%) patients, changes in serum creatinine during days 1–3 of the hospital stay exceeded 26.5 µmol/L; KeGFR values almost completely differentiated those with increasing and decreasing serum creatinine (area under receiver operating characteristic curve, AUROC: 0.990 on day 3). In twelve (8%) patients, renal failure was diagnosed during the first three days of the hospital stay according to the modified Marshall scoring system, which was associated with significantly lower KeGFR values. KeGFR offered good diagnostic accuracy for renal failure (area under receiver operating characteristic—AUROC: 0.942 and 0.950 on days 2 and 3). Fourteen (10%) patients developed severe AP. KeGFR enabled prediction of severe AP with moderate diagnostic accuracy (AUROC: 0.788 and 0.769 on days 2 and 3), independently of age, sex, comorbidities and study center. Lower KeGFR values were significantly associated with mortality. Significant dynamic changes in renal function are common in the early phase of AP. KeGFR may be useful in the assessment of kidney function in AP and the prediction of AP severity.
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spelling pubmed-96054462022-10-27 Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis Dumnicka, Paulina Mazur-Laskowska, Małgorzata Ceranowicz, Piotr Sporek, Mateusz Kolber, Witold Tisończyk, Joanna Kuźniewski, Marek Maziarz, Barbara Kuśnierz-Cabala, Beata J Clin Med Article In patients with acutely changing kidney function, equations used to estimate glomerular filtration rate (eGFR) must be adjusted for dynamic changes in the concentrations of filtration markers (kinetic eGFR, KeGFR). The aim of our study was to evaluate serum creatinine-based KeGFR in patients in the early phase of acute pancreatitis (AP) as a marker of changing renal function and as a predictor of AP severity. We retrospectively calculated KeGFR on day 2 and 3 of the hospital stay in a group of 147 adult patients admitted within 24 h from the onset of AP symptoms and treated in two secondary-care hospitals. In 34 (23%) patients, changes in serum creatinine during days 1–3 of the hospital stay exceeded 26.5 µmol/L; KeGFR values almost completely differentiated those with increasing and decreasing serum creatinine (area under receiver operating characteristic curve, AUROC: 0.990 on day 3). In twelve (8%) patients, renal failure was diagnosed during the first three days of the hospital stay according to the modified Marshall scoring system, which was associated with significantly lower KeGFR values. KeGFR offered good diagnostic accuracy for renal failure (area under receiver operating characteristic—AUROC: 0.942 and 0.950 on days 2 and 3). Fourteen (10%) patients developed severe AP. KeGFR enabled prediction of severe AP with moderate diagnostic accuracy (AUROC: 0.788 and 0.769 on days 2 and 3), independently of age, sex, comorbidities and study center. Lower KeGFR values were significantly associated with mortality. Significant dynamic changes in renal function are common in the early phase of AP. KeGFR may be useful in the assessment of kidney function in AP and the prediction of AP severity. MDPI 2022-10-19 /pmc/articles/PMC9605446/ /pubmed/36294481 http://dx.doi.org/10.3390/jcm11206159 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dumnicka, Paulina
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Sporek, Mateusz
Kolber, Witold
Tisończyk, Joanna
Kuźniewski, Marek
Maziarz, Barbara
Kuśnierz-Cabala, Beata
Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title_full Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title_fullStr Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title_full_unstemmed Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title_short Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis
title_sort acute changes in serum creatinine and kinetic glomerular filtration rate estimation in early phase of acute pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605446/
https://www.ncbi.nlm.nih.gov/pubmed/36294481
http://dx.doi.org/10.3390/jcm11206159
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