Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study

This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and incre...

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Autores principales: Angelovski, Marija, Hadzi-Petrushev, Nikola, Atanasov, Dino, Nikodinovski, Aleksandar, Mitrokhin, Vadim, Avtanski, Dimiter B., Mladenov, Mitko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605456/
https://www.ncbi.nlm.nih.gov/pubmed/36294901
http://dx.doi.org/10.3390/life12101466
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author Angelovski, Marija
Hadzi-Petrushev, Nikola
Atanasov, Dino
Nikodinovski, Aleksandar
Mitrokhin, Vadim
Avtanski, Dimiter B.
Mladenov, Mitko
author_facet Angelovski, Marija
Hadzi-Petrushev, Nikola
Atanasov, Dino
Nikodinovski, Aleksandar
Mitrokhin, Vadim
Avtanski, Dimiter B.
Mladenov, Mitko
author_sort Angelovski, Marija
collection PubMed
description This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-κB activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summary, OTC treatments exerted cardioprotective effects against MI in vivo, mainly due to enhancing cardiac antioxidant activity.
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spelling pubmed-96054562022-10-27 Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study Angelovski, Marija Hadzi-Petrushev, Nikola Atanasov, Dino Nikodinovski, Aleksandar Mitrokhin, Vadim Avtanski, Dimiter B. Mladenov, Mitko Life (Basel) Article This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-κB activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summary, OTC treatments exerted cardioprotective effects against MI in vivo, mainly due to enhancing cardiac antioxidant activity. MDPI 2022-09-21 /pmc/articles/PMC9605456/ /pubmed/36294901 http://dx.doi.org/10.3390/life12101466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Angelovski, Marija
Hadzi-Petrushev, Nikola
Atanasov, Dino
Nikodinovski, Aleksandar
Mitrokhin, Vadim
Avtanski, Dimiter B.
Mladenov, Mitko
Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title_full Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title_fullStr Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title_full_unstemmed Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title_short Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
title_sort protective effects of l-2-oxothiazolidine-4-carboxylate during isoproterenol-induced myocardial infarction in rats: in vivo study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605456/
https://www.ncbi.nlm.nih.gov/pubmed/36294901
http://dx.doi.org/10.3390/life12101466
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