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Reproductive Lifespan and Motor Progression of Parkinson’s Disease

Objectives: Estrogen not only plays a key role in the decreased risk of Parkinson’s disease (PD) but also influences its severity. We aimed to explore the effect of the reproductive lifespan on the motor progression of PD female patients in a large prospective cohort study. Methods: A competing risk...

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Autores principales: Ou, Ruwei, Wei, Qianqian, Hou, Yanbing, Zhang, Lingyu, Liu, Kuncheng, Lin, Junyu, Yang, Tianmi, Yang, Jing, Jiang, Zheng, Song, Wei, Cao, Bei, Shang, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605617/
https://www.ncbi.nlm.nih.gov/pubmed/36294482
http://dx.doi.org/10.3390/jcm11206163
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author Ou, Ruwei
Wei, Qianqian
Hou, Yanbing
Zhang, Lingyu
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Yang, Jing
Jiang, Zheng
Song, Wei
Cao, Bei
Shang, Huifang
author_facet Ou, Ruwei
Wei, Qianqian
Hou, Yanbing
Zhang, Lingyu
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Yang, Jing
Jiang, Zheng
Song, Wei
Cao, Bei
Shang, Huifang
author_sort Ou, Ruwei
collection PubMed
description Objectives: Estrogen not only plays a key role in the decreased risk of Parkinson’s disease (PD) but also influences its severity. We aimed to explore the effect of the reproductive lifespan on the motor progression of PD female patients in a large prospective cohort study. Methods: A competing risk analysis with a Fine and Gray model on 491 female and 609 male patients with PD was conducted. We regarded the chance of faster motor progression (as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS) III increasing by ≥16 points during follow-up) and the chance of death as competing risks. The reproductive lifespan was regarded as the variable of interest, while faster motor progression was set as the primary outcome. Results: In the multivariable competing risk analysis, the male sex was not significantly associated with faster motor progression (subdistribution hazard ratio (SHR) 0.888, 95% CI 0.652–1.209, p = 0.450), while a shorter reproductive lifespan was associated with faster motor progression in women (SHR 0.964, 95% CI 0.936–0.994, p = 0.019). Sensitivity analysis indicated that a shorter reproductive lifespan was also significantly associated with faster motor progression in the 48 female patients who reported menopause after the onset of PD (SHR 0.156, 95% CI 0.045–0.542, p = 0.003). A linear mixed model also revealed the significant main effects of a short reproductive lifespan on the higher UPDRS III score in PD female patients at the last visit (p = 0.026). Conclusions: Our study indicates that a short reproductive lifespan contributes to faster motor progression in PD female patients, which has important implications for understanding the role of endogenous estrogen exposure in female PD and is beneficial to select appropriate patients in clinical trials.
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spelling pubmed-96056172022-10-27 Reproductive Lifespan and Motor Progression of Parkinson’s Disease Ou, Ruwei Wei, Qianqian Hou, Yanbing Zhang, Lingyu Liu, Kuncheng Lin, Junyu Yang, Tianmi Yang, Jing Jiang, Zheng Song, Wei Cao, Bei Shang, Huifang J Clin Med Article Objectives: Estrogen not only plays a key role in the decreased risk of Parkinson’s disease (PD) but also influences its severity. We aimed to explore the effect of the reproductive lifespan on the motor progression of PD female patients in a large prospective cohort study. Methods: A competing risk analysis with a Fine and Gray model on 491 female and 609 male patients with PD was conducted. We regarded the chance of faster motor progression (as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS) III increasing by ≥16 points during follow-up) and the chance of death as competing risks. The reproductive lifespan was regarded as the variable of interest, while faster motor progression was set as the primary outcome. Results: In the multivariable competing risk analysis, the male sex was not significantly associated with faster motor progression (subdistribution hazard ratio (SHR) 0.888, 95% CI 0.652–1.209, p = 0.450), while a shorter reproductive lifespan was associated with faster motor progression in women (SHR 0.964, 95% CI 0.936–0.994, p = 0.019). Sensitivity analysis indicated that a shorter reproductive lifespan was also significantly associated with faster motor progression in the 48 female patients who reported menopause after the onset of PD (SHR 0.156, 95% CI 0.045–0.542, p = 0.003). A linear mixed model also revealed the significant main effects of a short reproductive lifespan on the higher UPDRS III score in PD female patients at the last visit (p = 0.026). Conclusions: Our study indicates that a short reproductive lifespan contributes to faster motor progression in PD female patients, which has important implications for understanding the role of endogenous estrogen exposure in female PD and is beneficial to select appropriate patients in clinical trials. MDPI 2022-10-19 /pmc/articles/PMC9605617/ /pubmed/36294482 http://dx.doi.org/10.3390/jcm11206163 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ou, Ruwei
Wei, Qianqian
Hou, Yanbing
Zhang, Lingyu
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Yang, Jing
Jiang, Zheng
Song, Wei
Cao, Bei
Shang, Huifang
Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title_full Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title_fullStr Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title_full_unstemmed Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title_short Reproductive Lifespan and Motor Progression of Parkinson’s Disease
title_sort reproductive lifespan and motor progression of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605617/
https://www.ncbi.nlm.nih.gov/pubmed/36294482
http://dx.doi.org/10.3390/jcm11206163
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