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Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022

BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for r...

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Autores principales: Boushab, Boushab Mohamed, Yanogo, Pauline K, Barry, Djibril, Benane, Hacen Ahmed, El Bara, Ahmed, Abdellah, Moussa, Basco, Leonardo K, Meda, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605700/
https://www.ncbi.nlm.nih.gov/pubmed/36320199
http://dx.doi.org/10.1093/ofid/ofac534
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author Boushab, Boushab Mohamed
Yanogo, Pauline K
Barry, Djibril
Benane, Hacen Ahmed
El Bara, Ahmed
Abdellah, Moussa
Basco, Leonardo K
Meda, Nicolas
author_facet Boushab, Boushab Mohamed
Yanogo, Pauline K
Barry, Djibril
Benane, Hacen Ahmed
El Bara, Ahmed
Abdellah, Moussa
Basco, Leonardo K
Meda, Nicolas
author_sort Boushab, Boushab Mohamed
collection PubMed
description BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent CCHF epidemic, capacity building, appropriate measures to treat patients, and information for the local population. METHODS: During the outbreak of hemorrhagic fever from February to May 2022, blood samples were collected from 88 patients suspected to be infected with the virus. Diagnosis was established by reverse-transcription polymerase chain reaction (RT-PCR) and/or enzyme-linked immunosorbent assay. RESULTS: CCHF was confirmed by RT-PCR in 7 of 88 (8%) patients. Ticks were found in cattle, sheep, or goats in the areas where the subjects resided, with the exception of 1 CCHF-positive patient in close contact with fresh animal meat. Exposure to potential risk factors was found in all patients. The interval between the onset of symptoms and hospital admission was 2–3 days. All 7 patients were admitted to our hospital and treated promptly by blood transfusion. Two patients died. CONCLUSIONS: Mortality is high in patients with the hemorrhagic form of CCHF. Disease prevention is necessary by strengthening vector control, avoiding contact and consumption of organic products from diseased animals, and vaccinating animals in areas where the disease is endemic. Furthermore, it is essential to establish management procedures for patients infected with CCHF virus.
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spelling pubmed-96057002022-10-31 Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022 Boushab, Boushab Mohamed Yanogo, Pauline K Barry, Djibril Benane, Hacen Ahmed El Bara, Ahmed Abdellah, Moussa Basco, Leonardo K Meda, Nicolas Open Forum Infect Dis Major Article BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent CCHF epidemic, capacity building, appropriate measures to treat patients, and information for the local population. METHODS: During the outbreak of hemorrhagic fever from February to May 2022, blood samples were collected from 88 patients suspected to be infected with the virus. Diagnosis was established by reverse-transcription polymerase chain reaction (RT-PCR) and/or enzyme-linked immunosorbent assay. RESULTS: CCHF was confirmed by RT-PCR in 7 of 88 (8%) patients. Ticks were found in cattle, sheep, or goats in the areas where the subjects resided, with the exception of 1 CCHF-positive patient in close contact with fresh animal meat. Exposure to potential risk factors was found in all patients. The interval between the onset of symptoms and hospital admission was 2–3 days. All 7 patients were admitted to our hospital and treated promptly by blood transfusion. Two patients died. CONCLUSIONS: Mortality is high in patients with the hemorrhagic form of CCHF. Disease prevention is necessary by strengthening vector control, avoiding contact and consumption of organic products from diseased animals, and vaccinating animals in areas where the disease is endemic. Furthermore, it is essential to establish management procedures for patients infected with CCHF virus. Oxford University Press 2022-10-12 /pmc/articles/PMC9605700/ /pubmed/36320199 http://dx.doi.org/10.1093/ofid/ofac534 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Article
Boushab, Boushab Mohamed
Yanogo, Pauline K
Barry, Djibril
Benane, Hacen Ahmed
El Bara, Ahmed
Abdellah, Moussa
Basco, Leonardo K
Meda, Nicolas
Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title_full Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title_fullStr Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title_full_unstemmed Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title_short Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
title_sort investigation around cases of crimean-congo hemorrhagic fever—mauritania, 2022
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605700/
https://www.ncbi.nlm.nih.gov/pubmed/36320199
http://dx.doi.org/10.1093/ofid/ofac534
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