Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-r...

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Detalles Bibliográficos
Autores principales: Chandna, Arjun, Mahajan, Raman, Gautam, Priyanka, Mwandigha, Lazaro, Kumar, Pragya, Varghese, George M, Koshiaris, Constantinos, Lubell, Yoel, Burza, Sakib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605705/
https://www.ncbi.nlm.nih.gov/pubmed/36320192
http://dx.doi.org/10.1093/ofid/ofac526
Descripción
Sumario:Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

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