Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-r...

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Autores principales: Chandna, Arjun, Mahajan, Raman, Gautam, Priyanka, Mwandigha, Lazaro, Kumar, Pragya, Varghese, George M, Koshiaris, Constantinos, Lubell, Yoel, Burza, Sakib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605705/
https://www.ncbi.nlm.nih.gov/pubmed/36320192
http://dx.doi.org/10.1093/ofid/ofac526
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author Chandna, Arjun
Mahajan, Raman
Gautam, Priyanka
Mwandigha, Lazaro
Kumar, Pragya
Varghese, George M
Koshiaris, Constantinos
Lubell, Yoel
Burza, Sakib
author_facet Chandna, Arjun
Mahajan, Raman
Gautam, Priyanka
Mwandigha, Lazaro
Kumar, Pragya
Varghese, George M
Koshiaris, Constantinos
Lubell, Yoel
Burza, Sakib
author_sort Chandna, Arjun
collection PubMed
description Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.
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spelling pubmed-96057052022-10-31 Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study Chandna, Arjun Mahajan, Raman Gautam, Priyanka Mwandigha, Lazaro Kumar, Pragya Varghese, George M Koshiaris, Constantinos Lubell, Yoel Burza, Sakib Open Forum Infect Dis Brief Report Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases. Oxford University Press 2022-10-06 /pmc/articles/PMC9605705/ /pubmed/36320192 http://dx.doi.org/10.1093/ofid/ofac526 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Chandna, Arjun
Mahajan, Raman
Gautam, Priyanka
Mwandigha, Lazaro
Kumar, Pragya
Varghese, George M
Koshiaris, Constantinos
Lubell, Yoel
Burza, Sakib
Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title_full Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title_fullStr Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title_full_unstemmed Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title_short Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
title_sort host biomarkers reflect prognosis in patients presenting with moderate coronavirus disease 2019: a prospective cohort study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605705/
https://www.ncbi.nlm.nih.gov/pubmed/36320192
http://dx.doi.org/10.1093/ofid/ofac526
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