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Numerical investigation of flexible Purcell-like integrated microfluidic pumps

Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has...

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Detalles Bibliográficos
Autores principales: Binsley, Jacob L., Pagliara, Stefano, Ogrin, Feodor Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605776/
https://www.ncbi.nlm.nih.gov/pubmed/36313737
http://dx.doi.org/10.1063/5.0109263
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author Binsley, Jacob L.
Pagliara, Stefano
Ogrin, Feodor Y.
author_facet Binsley, Jacob L.
Pagliara, Stefano
Ogrin, Feodor Y.
author_sort Binsley, Jacob L.
collection PubMed
description Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in COMSOL Multiphysics and its performance has been investigated and evaluated. An elastic, cilia-like element contains an embedded magnet, which allows for actuation via a weak, uniaxial, sinusoidally oscillating, external magnetic field. Pumping performance is correlated against a number of variables, such as the frequency of the driving field and the proximity of the pump to the channel walls, in order to understand the emergence of the pumping behavior. Crucially, these simulations capture many of the trends observed experimentally and shed light on the key interactions. The proximity of the channel walls in the in-plane direction strongly determines the direction of net fluid flow. This characterization has important implications for the design and optimization of this pump in practical applications.
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spelling pubmed-96057762022-10-27 Numerical investigation of flexible Purcell-like integrated microfluidic pumps Binsley, Jacob L. Pagliara, Stefano Ogrin, Feodor Y. J Appl Phys ARTICLES Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in COMSOL Multiphysics and its performance has been investigated and evaluated. An elastic, cilia-like element contains an embedded magnet, which allows for actuation via a weak, uniaxial, sinusoidally oscillating, external magnetic field. Pumping performance is correlated against a number of variables, such as the frequency of the driving field and the proximity of the pump to the channel walls, in order to understand the emergence of the pumping behavior. Crucially, these simulations capture many of the trends observed experimentally and shed light on the key interactions. The proximity of the channel walls in the in-plane direction strongly determines the direction of net fluid flow. This characterization has important implications for the design and optimization of this pump in practical applications. AIP Publishing LLC 2022-10-28 2022-10-25 /pmc/articles/PMC9605776/ /pubmed/36313737 http://dx.doi.org/10.1063/5.0109263 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle ARTICLES
Binsley, Jacob L.
Pagliara, Stefano
Ogrin, Feodor Y.
Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title_full Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title_fullStr Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title_full_unstemmed Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title_short Numerical investigation of flexible Purcell-like integrated microfluidic pumps
title_sort numerical investigation of flexible purcell-like integrated microfluidic pumps
topic ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605776/
https://www.ncbi.nlm.nih.gov/pubmed/36313737
http://dx.doi.org/10.1063/5.0109263
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