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Numerical investigation of flexible Purcell-like integrated microfluidic pumps
Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605776/ https://www.ncbi.nlm.nih.gov/pubmed/36313737 http://dx.doi.org/10.1063/5.0109263 |
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author | Binsley, Jacob L. Pagliara, Stefano Ogrin, Feodor Y. |
author_facet | Binsley, Jacob L. Pagliara, Stefano Ogrin, Feodor Y. |
author_sort | Binsley, Jacob L. |
collection | PubMed |
description | Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in COMSOL Multiphysics and its performance has been investigated and evaluated. An elastic, cilia-like element contains an embedded magnet, which allows for actuation via a weak, uniaxial, sinusoidally oscillating, external magnetic field. Pumping performance is correlated against a number of variables, such as the frequency of the driving field and the proximity of the pump to the channel walls, in order to understand the emergence of the pumping behavior. Crucially, these simulations capture many of the trends observed experimentally and shed light on the key interactions. The proximity of the channel walls in the in-plane direction strongly determines the direction of net fluid flow. This characterization has important implications for the design and optimization of this pump in practical applications. |
format | Online Article Text |
id | pubmed-9605776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-96057762022-10-27 Numerical investigation of flexible Purcell-like integrated microfluidic pumps Binsley, Jacob L. Pagliara, Stefano Ogrin, Feodor Y. J Appl Phys ARTICLES Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in COMSOL Multiphysics and its performance has been investigated and evaluated. An elastic, cilia-like element contains an embedded magnet, which allows for actuation via a weak, uniaxial, sinusoidally oscillating, external magnetic field. Pumping performance is correlated against a number of variables, such as the frequency of the driving field and the proximity of the pump to the channel walls, in order to understand the emergence of the pumping behavior. Crucially, these simulations capture many of the trends observed experimentally and shed light on the key interactions. The proximity of the channel walls in the in-plane direction strongly determines the direction of net fluid flow. This characterization has important implications for the design and optimization of this pump in practical applications. AIP Publishing LLC 2022-10-28 2022-10-25 /pmc/articles/PMC9605776/ /pubmed/36313737 http://dx.doi.org/10.1063/5.0109263 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | ARTICLES Binsley, Jacob L. Pagliara, Stefano Ogrin, Feodor Y. Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title | Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title_full | Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title_fullStr | Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title_full_unstemmed | Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title_short | Numerical investigation of flexible Purcell-like integrated microfluidic pumps |
title_sort | numerical investigation of flexible purcell-like integrated microfluidic pumps |
topic | ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605776/ https://www.ncbi.nlm.nih.gov/pubmed/36313737 http://dx.doi.org/10.1063/5.0109263 |
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