Novel antigen-presenting cell imparts T(reg)-dependent tolerance to gut microbiota

Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion of aut...

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Detalles Bibliográficos
Autores principales: Akagbosu, Blossom, Tayyebi, Zakieh, Shibu, Gayathri, Paucar Iza, Yoselin A., Deep, Deeksha, Parisotto, Yollanda Franco, Fisher, Logan, Pasolli, H. Amalia, Thevin, Valentin, Elmentaite, Rasa, Knott, Maximilian, Hemmers, Saskia, Jahn, Lorenz, Friedrich, Christin, Verter, Jacob, Wang, Zhong-Min, van den Brink, Marcel, Gasteiger, Georg, Grünewald, Thomas G. P., Marie, Julien C., Leslie, Christina, Rudensky, Alexander Y., Brown, Chrysothemis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605865/
https://www.ncbi.nlm.nih.gov/pubmed/36070798
http://dx.doi.org/10.1038/s41586-022-05309-5

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