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A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin

As single- and mixed-species biofilms, Staphylococcus aureus and Pseudomonas aeruginosa cause difficult-to-eradicate chronic infections. In P. aeruginosa, pseudomonas quinolone (PQS)-dependent quorum sensing regulates virulence and biofilm development that can be attenuated via antagonists targeting...

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Detalles Bibliográficos
Autores principales:	Murray, Ewan J., Dubern, Jean-Frédéric, Chan, Weng C., Chhabra, Siri Ram, Williams, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605878/ https://www.ncbi.nlm.nih.gov/pubmed/35259345 http://dx.doi.org/10.1016/j.chembiol.2022.02.007

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