Cargando…

Proposal for the use of an inhalation drug containing 2-5 oligoadenylates for treatment of COVID-19

Interferons (IFN), first described 1957 by Isaacs and Lindemann, are antiviral proteins generated in cells after viral infections. One of several interferon-induced effector mechanisms is the so called 2-5A / RNaseL system: Interferon is produced in the virus-affected cells and released. After bindi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bruchelt, Gernot, Treuner, Jörn, Schmidt, Karlheinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605919/ https://www.ncbi.nlm.nih.gov/pubmed/36317071 http://dx.doi.org/10.1016/j.mehy.2022.110969

Ejemplares similares

2′‐5′ oligoadenylate synthetase 1 polymorphism is associated with prostate cancer
por: Mandal, Sanjay, et al.
Publicado: (2011)

Innate Resistance to Flavivirus Infections and the Functions of 2′-5′ Oligoadenylate Synthetases
por: Mashimo, T., et al.
Publicado: (2008)

Origin and development of oligoadenylate synthetase immune system
por: Hu, Jiaxiang, et al.
Publicado: (2018)

Uridylation prevents 3′ trimming of oligoadenylated mRNAs
por: Sement, François Michaël, et al.
Publicado: (2013)

A novel RNA molecular signature for activation of 2′-5′ oligoadenylate synthetase-1
por: Vachon, Virginia K., et al.
Publicado: (2015)

Activation of 2′ 5′-Oligoadenylate Synthetase by Stem Loops at the 5′-End of the West Nile Virus Genome
por: Deo, Soumya, et al.
Publicado: (2014)

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence
por: Grüschow, Sabine, et al.
Publicado: (2019)

Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2
por: Koul, Amit, et al.
Publicado: (2020)

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation
por: Oakes, Samantha R., et al.
Publicado: (2017)

2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study
por: Wu, Shouquan, et al.
Publicado: (2018)

Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases
por: Choi, Un Yung, et al.
Publicado: (2015)

Control of cyclic oligoadenylate synthesis in a type III CRISPR system
por: Rouillon, Christophe, et al.
Publicado: (2018)

The Cyclic Oligoadenylate Signaling Pathway of Type III CRISPR-Cas Systems
por: Huang, Fengtao, et al.
Publicado: (2021)

Genetic Ethnic Differences in Human 2′-5′-Oligoadenylate Synthetase and Disease Associations: A Systematic Review
por: Gokul, Anmol, et al.
Publicado: (2023)

Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L
por: Anderson, Bart R., et al.
Publicado: (2011)

2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
por: Haralambieva, Iana H., et al.
Publicado: (2010)

A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines
por: Bhosle, Sushma M., et al.
Publicado: (2016)

Ring nucleases deactivate Type III CRISPR ribonucleases by degrading cyclic oligoadenylate
por: Athukoralage, Januka S, et al.
Publicado: (2018)

Regulation of cyclic oligoadenylate synthesis by the Staphylococcus epidermidis Cas10-Csm complex
por: Nasef, Mohamed, et al.
Publicado: (2019)

Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes
por: Rios, Jonathan J, et al.
Publicado: (2007)

Association of dengue virus infection susceptibility with polymorphisms of 2′-5′-oligoadenylate synthetase genes: a case–control study
por: Thamizhmani, Ramanathan, et al.
Publicado: (2014)

Oligoadenylation of 3′ decay intermediates promotes cytoplasmic mRNA degradation in Drosophila cells
por: Harnisch, Christiane, et al.
Publicado: (2016)

A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator
por: Athukoralage, Januka S., et al.
Publicado: (2019)

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6
por: Garcia-Doval, Carmela, et al.
Publicado: (2020)

Oligoadenylate synthetases-like is a prognostic biomarker and therapeutic target in pancreatic ductal adenocarcinoma
por: Chen, Shihong, et al.
Publicado: (2022)

Cyclic oligoadenylate signaling and regulation by ring nucleases during type III CRISPR defense
por: Athukoralage, Januka S., et al.
Publicado: (2021)

The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2’-5’ Oligoadenylate Synthetase-Like Protein
por: Shepard, Justin D., et al.
Publicado: (2022)

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage
por: Athukoralage, Januka S, et al.
Publicado: (2020)

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
por: McMahon, Stephen A., et al.
Publicado: (2020)

Role of the chicken oligoadenylate synthase-like gene during in vitro Newcastle disease virus infection
por: Del Vesco, Ana Paula, et al.
Publicado: (2021)

Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases
por: Molina, Rafael, et al.
Publicado: (2021)

Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
por: Molina, Rafael, et al.
Publicado: (2022)

The Cellular Localization of the p42 and p46 Oligoadenylate Synthetase 1 Isoforms and Their Impact on Mitochondrial Respiration
por: Skrivergaard, Stig, et al.
Publicado: (2019)

Hybrid Molecules of Benzylguanidine and the Alkylating Group of Melphalan: Synthesis and Effects on Neuroblastoma Cells
por: Bruchelt, Gernot, et al.
Publicado: (2023)

Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy
por: Sim, Chan Kyu, et al.
Publicado: (2019)

Polymorphism of 2′-5′-oligoadenylate synthetase (OAS) genes, associated with predisposition to severe forms of tick-borne encephalitis, in human populations of North Eurasia
por: Barkhash, A. V., et al.
Publicado: (2010)

2′, 5′-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway
por: Liao, Xinzhong, et al.
Publicado: (2020)

Antivirals and the Potential Benefits of Orally Inhaled Drug Administration in COVID-19 Treatment
por: Sahin, Gokben, et al.
Publicado: (2022)

Inhalable antibodies for the treatment of COVID-19
por: Yang, Zhenlin, et al.
Publicado: (2022)

Inhaled corticosteroids for the treatment of COVID-19
por: Bafadhel, Mona, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6n7dgrmvc6f4do3anosvvrmtl8