METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions

The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 expression inversely correlates with node metastasis in human cancers. It remains unclear if nuclear METTL3 is functionally distinct from cy...

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Detalles Bibliográficos
Autores principales: Li, Yuanpei, He, Xiaoniu, Lu, Xiao, Gong, Zhicheng, Li, Qing, Zhang, Lei, Yang, Ronghui, Wu, Chengyi, Huang, Jialiang, Ding, Jiancheng, He, Yaohui, Liu, Wen, Chen, Ceshi, Cao, Bin, Zhou, Dawang, Shi, Yufeng, Chen, Juxiang, Wang, Chuangui, Zhang, Shengping, Zhang, Jian, Ye, Jing, You, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605963/
https://www.ncbi.nlm.nih.gov/pubmed/36289222
http://dx.doi.org/10.1038/s41467-022-34209-5

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