Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films

Highly bond-specific fragmentation of oligopeptides induced by swift heavy ion (SHI) irradiation was investigated by means of mass spectrometry. In pronounced contrast to measurements of samples irradiated with keV ions, oligopeptides which were exposed to 946 MeV Au ions show a high abundance of sp...

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Autores principales: Schneider, P., Keller, P., Schubert, I., Bender, M., Trautmann, C., Dürr, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605986/
https://www.ncbi.nlm.nih.gov/pubmed/36289262
http://dx.doi.org/10.1038/s41598-022-21744-w
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author Schneider, P.
Keller, P.
Schubert, I.
Bender, M.
Trautmann, C.
Dürr, M.
author_facet Schneider, P.
Keller, P.
Schubert, I.
Bender, M.
Trautmann, C.
Dürr, M.
author_sort Schneider, P.
collection PubMed
description Highly bond-specific fragmentation of oligopeptides induced by swift heavy ion (SHI) irradiation was investigated by means of mass spectrometry. In pronounced contrast to measurements of samples irradiated with keV ions, oligopeptides which were exposed to 946 MeV Au ions show a high abundance of specific fragments. The highly bond-specific nature of SHI-induced fragmentation is attributed to electronic stopping as the most relevant energy loss mechanism for SHI in the oligopeptide samples in combination with the subsequent coupling between the excited electronic and the atomic subsystem. Fragmentation induced by SHI is observed to be further influenced by the structure of the oligopeptides, suggesting that electronic excitation and/or the electronic-vibrational coupling depend on the details of the molecular structure.
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spelling pubmed-96059862022-10-28 Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films Schneider, P. Keller, P. Schubert, I. Bender, M. Trautmann, C. Dürr, M. Sci Rep Article Highly bond-specific fragmentation of oligopeptides induced by swift heavy ion (SHI) irradiation was investigated by means of mass spectrometry. In pronounced contrast to measurements of samples irradiated with keV ions, oligopeptides which were exposed to 946 MeV Au ions show a high abundance of specific fragments. The highly bond-specific nature of SHI-induced fragmentation is attributed to electronic stopping as the most relevant energy loss mechanism for SHI in the oligopeptide samples in combination with the subsequent coupling between the excited electronic and the atomic subsystem. Fragmentation induced by SHI is observed to be further influenced by the structure of the oligopeptides, suggesting that electronic excitation and/or the electronic-vibrational coupling depend on the details of the molecular structure. Nature Publishing Group UK 2022-10-26 /pmc/articles/PMC9605986/ /pubmed/36289262 http://dx.doi.org/10.1038/s41598-022-21744-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Schneider, P.
Keller, P.
Schubert, I.
Bender, M.
Trautmann, C.
Dürr, M.
Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title_full Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title_fullStr Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title_full_unstemmed Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title_short Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
title_sort bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605986/
https://www.ncbi.nlm.nih.gov/pubmed/36289262
http://dx.doi.org/10.1038/s41598-022-21744-w
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