Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor

The F-box protein beta-transducin repeat containing protein (β-TrCP) acts as a substrate adapter for the SCF E3 ubiquitin ligase complex, plays a crucial role in cell physiology, and is often deregulated in many types of cancers. Here, we develop a fluorescent biosensor to quantitatively measure β-T...

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Detalles Bibliográficos
Autores principales: Paul, Debasish, Kales, Stephen C., Cornwell, James A., Afifi, Marwa M., Rai, Ganesha, Zakharov, Alexey, Simeonov, Anton, Cappell, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606124/
https://www.ncbi.nlm.nih.gov/pubmed/36289220
http://dx.doi.org/10.1038/s41467-022-33762-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606124/
https://www.ncbi.nlm.nih.gov/pubmed/36289220
http://dx.doi.org/10.1038/s41467-022-33762-3

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