Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese

Activation of the alternative pathway (AP) of complement is thought to play an important role in Immunoglobin A nephropathy (IgAN). Our previous study showed that rs4151657 within the complement factor B (CFB) gene increased the risk of IgAN. The protein encoded by the CFB gene is an initial factor...

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Detalles Bibliográficos
Autores principales: Shi, Dian-Chun, Feng, Shao-Zhen, Zhong, Zhong, Cai, Lu, Wang, Meng, Fu, Dong-Ying, Yu, Xue-Qing, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606215/
https://www.ncbi.nlm.nih.gov/pubmed/36311737
http://dx.doi.org/10.3389/fimmu.2022.973169

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