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Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently a...

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Autores principales: Mennigen, Jan A., Ramachandran, Divya, Shaw, Katherine, Chaube, Radha, Joy, Keerikkattil P., Trudeau, Vance L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606234/
https://www.ncbi.nlm.nih.gov/pubmed/36313759
http://dx.doi.org/10.3389/fendo.2022.1005863
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author Mennigen, Jan A.
Ramachandran, Divya
Shaw, Katherine
Chaube, Radha
Joy, Keerikkattil P.
Trudeau, Vance L.
author_facet Mennigen, Jan A.
Ramachandran, Divya
Shaw, Katherine
Chaube, Radha
Joy, Keerikkattil P.
Trudeau, Vance L.
author_sort Mennigen, Jan A.
collection PubMed
description The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently allowed new insight into the evolution of nonapeptides and especially their receptor families in the context of whole genome duplications. In bony fish, nonapeptide homologues of AVP termed arginine vasotocin (Avp) and an OXT family peptide (Oxt) originally termed isotocin have been characterized. While reproductive roles of both nonapeptide families have historically been studied in several vertebrates, their roles in teleost reproduction remain much less understood. Taking advantage of novel genome resources and associated technological advances such as genetic modifications in fish models, we here critically review the current state of knowledge regarding the roles of nonapeptide systems in teleost reproduction. We further discuss sources of plasticity of the conserved nonapeptide systems in the context of diverse reproductive phenotypes observed in teleost fishes. Given the dual roles of preoptic area (POA) synthesized Avp and Oxt as neuromodulators and endocrine/paracrine factors, we focus on known roles of both peptides on reproductive behaviour and the regulation of the hypothalamic-pituitary-gonadal axis. Emphasis is placed on the identification of a gonadal nonapeptide system that plays critical roles in both steroidogenesis and gamete maturation. We conclude by highlighting key research gaps including a call for translational studies linking new mechanistic understanding of nonapeptide regulated physiology in the context of aquaculture, conservation biology and ecotoxicology.
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spelling pubmed-96062342022-10-28 Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes Mennigen, Jan A. Ramachandran, Divya Shaw, Katherine Chaube, Radha Joy, Keerikkattil P. Trudeau, Vance L. Front Endocrinol (Lausanne) Endocrinology The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently allowed new insight into the evolution of nonapeptides and especially their receptor families in the context of whole genome duplications. In bony fish, nonapeptide homologues of AVP termed arginine vasotocin (Avp) and an OXT family peptide (Oxt) originally termed isotocin have been characterized. While reproductive roles of both nonapeptide families have historically been studied in several vertebrates, their roles in teleost reproduction remain much less understood. Taking advantage of novel genome resources and associated technological advances such as genetic modifications in fish models, we here critically review the current state of knowledge regarding the roles of nonapeptide systems in teleost reproduction. We further discuss sources of plasticity of the conserved nonapeptide systems in the context of diverse reproductive phenotypes observed in teleost fishes. Given the dual roles of preoptic area (POA) synthesized Avp and Oxt as neuromodulators and endocrine/paracrine factors, we focus on known roles of both peptides on reproductive behaviour and the regulation of the hypothalamic-pituitary-gonadal axis. Emphasis is placed on the identification of a gonadal nonapeptide system that plays critical roles in both steroidogenesis and gamete maturation. We conclude by highlighting key research gaps including a call for translational studies linking new mechanistic understanding of nonapeptide regulated physiology in the context of aquaculture, conservation biology and ecotoxicology. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606234/ /pubmed/36313759 http://dx.doi.org/10.3389/fendo.2022.1005863 Text en Copyright © 2022 Mennigen, Ramachandran, Shaw, Chaube, Joy and Trudeau https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mennigen, Jan A.
Ramachandran, Divya
Shaw, Katherine
Chaube, Radha
Joy, Keerikkattil P.
Trudeau, Vance L.
Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title_full Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title_fullStr Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title_full_unstemmed Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title_short Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
title_sort reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606234/
https://www.ncbi.nlm.nih.gov/pubmed/36313759
http://dx.doi.org/10.3389/fendo.2022.1005863
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