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Integrated proteomic and metabolomic profile analyses of cardiac valves revealed molecular mechanisms and targets in calcific aortic valve disease

BACKGROUND: This study aimed to define changes in the metabolic and protein profiles of patients with calcific aortic valve disease (CAVD). METHODS AND RESULTS: We analyzed cardiac valve samples of patients with and without (control) CAVD (n = 24 per group) using untargeted metabolomics and tandem m...

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Detalles Bibliográficos
Autores principales: Fu, Bo, Wang, Jing, Wang, Lianqun, Wang, Qiang, Guo, Zhigang, Xu, Meilin, Jiang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606238/
https://www.ncbi.nlm.nih.gov/pubmed/36312243
http://dx.doi.org/10.3389/fcvm.2022.944521