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Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine
To investigate the effect of monoglyceryl laurate (GML) against PEDV in vivo, the clinical signs, pathological changes, tissue viral load and cytokine levels of piglets were compared in different GML treatment groups and PEDV infected group. The diets of experimental groups were supplemented with di...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606319/ https://www.ncbi.nlm.nih.gov/pubmed/36311680 http://dx.doi.org/10.3389/fvets.2022.980381 |
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author | Liu, Zheyan Zhu, Ling Zhao, Xiaonan Liu, Jian Cheng, Huangzuo Zhang, Lina Tang, Huaqiao Sun, Xiangang Hu, Youjun Xu, Zhiwen |
author_facet | Liu, Zheyan Zhu, Ling Zhao, Xiaonan Liu, Jian Cheng, Huangzuo Zhang, Lina Tang, Huaqiao Sun, Xiangang Hu, Youjun Xu, Zhiwen |
author_sort | Liu, Zheyan |
collection | PubMed |
description | To investigate the effect of monoglyceryl laurate (GML) against PEDV in vivo, the clinical signs, pathological changes, tissue viral load and cytokine levels of piglets were compared in different GML treatment groups and PEDV infected group. The diets of experimental groups were supplemented with different doses of GML (5g for A1, 10g for A2, 20g for A3) on day 1, 2, and 3 after PEDV challenge, and the virus challenge group (group C) and blank group (group B) were set as control. The results showed that compared with group C, groups As could reduce the mortality rate of piglets, among which the protection rates of groups A2 and A3 could reach 100%. The trend of weight loss of piglets was effectively slowed down and growth performance recovered in GML treated groups. GML reduced the pathological damage of intestinal tract and the viral load in intestine and mesenteric lymph nodes. The levels of IL-8 and TNF-α in the blood of group As were inhibited by GML in a dose-dependent manner when compared with group C. Our study suggests that GML has potential anti-PEDV effects in vivo. |
format | Online Article Text |
id | pubmed-9606319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96063192022-10-28 Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine Liu, Zheyan Zhu, Ling Zhao, Xiaonan Liu, Jian Cheng, Huangzuo Zhang, Lina Tang, Huaqiao Sun, Xiangang Hu, Youjun Xu, Zhiwen Front Vet Sci Veterinary Science To investigate the effect of monoglyceryl laurate (GML) against PEDV in vivo, the clinical signs, pathological changes, tissue viral load and cytokine levels of piglets were compared in different GML treatment groups and PEDV infected group. The diets of experimental groups were supplemented with different doses of GML (5g for A1, 10g for A2, 20g for A3) on day 1, 2, and 3 after PEDV challenge, and the virus challenge group (group C) and blank group (group B) were set as control. The results showed that compared with group C, groups As could reduce the mortality rate of piglets, among which the protection rates of groups A2 and A3 could reach 100%. The trend of weight loss of piglets was effectively slowed down and growth performance recovered in GML treated groups. GML reduced the pathological damage of intestinal tract and the viral load in intestine and mesenteric lymph nodes. The levels of IL-8 and TNF-α in the blood of group As were inhibited by GML in a dose-dependent manner when compared with group C. Our study suggests that GML has potential anti-PEDV effects in vivo. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606319/ /pubmed/36311680 http://dx.doi.org/10.3389/fvets.2022.980381 Text en Copyright © 2022 Liu, Zhu, Zhao, Liu, Cheng, Zhang, Tang, Sun, Hu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Liu, Zheyan Zhu, Ling Zhao, Xiaonan Liu, Jian Cheng, Huangzuo Zhang, Lina Tang, Huaqiao Sun, Xiangang Hu, Youjun Xu, Zhiwen Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title | Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title_full | Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title_fullStr | Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title_full_unstemmed | Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title_short | Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine |
title_sort | effects of oral of administration of monoglycide laurate on virus load and inflammation in pedv infected porcine |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606319/ https://www.ncbi.nlm.nih.gov/pubmed/36311680 http://dx.doi.org/10.3389/fvets.2022.980381 |
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