Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

In addition to autoimmune and inflammatory diseases, variants of the TNFAIP3 gene encoding the ubiquitin-editing enzyme A20 are also associated with fibrosis in systemic sclerosis (SSc). However, it remains unclear how genetic factors contribute to SSc pathogenesis, and which cell types drive the di...

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Detalles Bibliográficos
Autores principales: Wang, Wenxia, Bale, Swarna, Wei, Jun, Yalavarthi, Bharath, Bhattacharyya, Dibyendu, Yan, Jing Jing, Abdala-Valencia, Hiam, Xu, Dan, Sun, Hanshi, Marangoni, Roberta G., Herzog, Erica, Berdnikovs, Sergejs, Miller, Stephen D., Sawalha, Amr H., Tsou, Pei-Suen, Awaji, Kentaro, Yamashita, Takashi, Sato, Shinichi, Asano, Yoshihide, Tiruppathi, Chinnaswamy, Yeldandi, Anjana, Schock, Bettina C., Bhattacharyya, Swati, Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606375/
https://www.ncbi.nlm.nih.gov/pubmed/36289219
http://dx.doi.org/10.1038/s41467-022-33767-y

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