The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview

Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critica...

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Autores principales: Shen, Xiao-yue, Shi, Shu-han, Li, Heng, Wang, Cong-cong, Zhang, Yao, Yu, Hui, Li, Yan-bin, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606402/
https://www.ncbi.nlm.nih.gov/pubmed/36311022
http://dx.doi.org/10.3389/fnmol.2022.1021207
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author Shen, Xiao-yue
Shi, Shu-han
Li, Heng
Wang, Cong-cong
Zhang, Yao
Yu, Hui
Li, Yan-bin
Liu, Bin
author_facet Shen, Xiao-yue
Shi, Shu-han
Li, Heng
Wang, Cong-cong
Zhang, Yao
Yu, Hui
Li, Yan-bin
Liu, Bin
author_sort Shen, Xiao-yue
collection PubMed
description Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critical role in epigenetic DNA demethylation, neuroplasticity, and neuroprotection, according to accumulating evidence. This article provided an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, focusing on major psychosis, depression, autism, stroke, seizure, dementia, Parkinson’s disease, and autoimmune diseases of the nervous system.
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spelling pubmed-96064022022-10-28 The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview Shen, Xiao-yue Shi, Shu-han Li, Heng Wang, Cong-cong Zhang, Yao Yu, Hui Li, Yan-bin Liu, Bin Front Mol Neurosci Molecular Neuroscience Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critical role in epigenetic DNA demethylation, neuroplasticity, and neuroprotection, according to accumulating evidence. This article provided an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, focusing on major psychosis, depression, autism, stroke, seizure, dementia, Parkinson’s disease, and autoimmune diseases of the nervous system. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606402/ /pubmed/36311022 http://dx.doi.org/10.3389/fnmol.2022.1021207 Text en Copyright © 2022 Shen, Shi, Li, Wang, Zhang, Yu, Li and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Shen, Xiao-yue
Shi, Shu-han
Li, Heng
Wang, Cong-cong
Zhang, Yao
Yu, Hui
Li, Yan-bin
Liu, Bin
The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title_full The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title_fullStr The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title_full_unstemmed The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title_short The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
title_sort role of gadd45b in neurologic and neuropsychiatric disorders: an overview
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606402/
https://www.ncbi.nlm.nih.gov/pubmed/36311022
http://dx.doi.org/10.3389/fnmol.2022.1021207
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