EZH2: Its regulation and roles in immune disturbance of SLE

The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is cur...

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Autores principales: Yang, Yiying, Liu, Ke, Liu, Meidong, Zhang, Huali, Guo, Muyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606410/
https://www.ncbi.nlm.nih.gov/pubmed/36313363
http://dx.doi.org/10.3389/fphar.2022.1002741
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author Yang, Yiying
Liu, Ke
Liu, Meidong
Zhang, Huali
Guo, Muyao
author_facet Yang, Yiying
Liu, Ke
Liu, Meidong
Zhang, Huali
Guo, Muyao
author_sort Yang, Yiying
collection PubMed
description The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is currently found to participate in the pathogenesis of SLE through affecting multiple components of the immune system. This review mainly expounds the mechanisms underlying EZH2-mediated disruption of immune homeostasis in SLE patients, hoping to provide new ideas in the pathogenesis of SLE and new targets for future treatment.
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spelling pubmed-96064102022-10-28 EZH2: Its regulation and roles in immune disturbance of SLE Yang, Yiying Liu, Ke Liu, Meidong Zhang, Huali Guo, Muyao Front Pharmacol Pharmacology The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is currently found to participate in the pathogenesis of SLE through affecting multiple components of the immune system. This review mainly expounds the mechanisms underlying EZH2-mediated disruption of immune homeostasis in SLE patients, hoping to provide new ideas in the pathogenesis of SLE and new targets for future treatment. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606410/ /pubmed/36313363 http://dx.doi.org/10.3389/fphar.2022.1002741 Text en Copyright © 2022 Yang, Liu, Liu, Zhang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Yiying
Liu, Ke
Liu, Meidong
Zhang, Huali
Guo, Muyao
EZH2: Its regulation and roles in immune disturbance of SLE
title EZH2: Its regulation and roles in immune disturbance of SLE
title_full EZH2: Its regulation and roles in immune disturbance of SLE
title_fullStr EZH2: Its regulation and roles in immune disturbance of SLE
title_full_unstemmed EZH2: Its regulation and roles in immune disturbance of SLE
title_short EZH2: Its regulation and roles in immune disturbance of SLE
title_sort ezh2: its regulation and roles in immune disturbance of sle
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606410/
https://www.ncbi.nlm.nih.gov/pubmed/36313363
http://dx.doi.org/10.3389/fphar.2022.1002741
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AT zhanghuali ezh2itsregulationandrolesinimmunedisturbanceofsle
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