Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1

OBJECTIVE: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. METHODS: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy contr...

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Detalles Bibliográficos
Autores principales: Lu, Tsung-Hua, Lin, Shih-Hsien, Tseng, Huai-Hsuan, Yang, Yen Kuang, Chiu, Nan Tsing, Chen, Po See
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606428/
https://www.ncbi.nlm.nih.gov/pubmed/36263651
http://dx.doi.org/10.9758/cpn.2022.20.4.768
Descripción
Sumario:OBJECTIVE: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. METHODS: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT-1. RESULTS: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. CONCLUSION: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.

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